Symbol
Name
ID

Tnfsf11
tumor necrosis factor (ligand) superfamily, member 11
MGI:1100089

Phenotype annotations related to skeleton

*	Aspects of the system are reported to show a normal phenotype.
!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes	Cranial hyperostosis	Mandibular osteomyelitis	Mandibular prognathia	Genu valgum	Diaphyseal sclerosis	Osteomyelitis	Recurrent fractures	Osteopetrosis	Osteoporosis	Decreased osteoclast count
Disease(s) Associated with TNFSF11	Cranial hyperostosis	Mandibular osteomyelitis	Mandibular prognathia	Genu valgum	Diaphyseal sclerosis	Osteomyelitis	Recurrent fractures	Osteopetrosis	Osteoporosis	Decreased osteoclast count
autosomal recessive osteopetrosis 2
osteoporosis

Mouse Phenotypes

skeleton phenotype

abnormal osteoblast physiology

abnormal craniofacial bone morphology

abnormal cranial suture morphology

optic canal stenosis

decreased cranium height

small cranium

abnormal neurocranium morphology

thin neurocranium

abnormal hyoid bone body morphology

failure of tooth eruption

supernumerary teeth

mandible hypoplasia

abnormal zygomatic bone morphology

decreased osteoclast cell number

increased osteoclast cell number

abnormal osteoclast morphology

abnormal osteoclast cell number

decreased internal diameter of femur

increased diameter of tibia

short tibia

abnormal long bone epiphyseal plate morphology

abnormal long bone epiphyseal plate proliferative zone

increased width of hypertrophic chondrocyte zone

increased long bone epiphyseal plate size

abnormal long bone internal diameter

abnormal long bone metaphysis morphology

decreased length of long bones

increased diameter of long bones

abnormal pelvic girdle bone morphology

kyphosis

increased bone mineral density of vertebrae

short vertebral column

abnormal bone structure

abnormal bone marrow morphology

increased bone mineral content

abnormal areal bone mineral density

increased areal bone mineral density

decreased bone mineral density of femur

increased bone mineral density of femur

decreased bone mineral density

increased bone mineral density

increased trabecular bone volume

increased bone volume

decreased compact bone thickness

abnormal trabecular bone morphology

decreased bone trabecula number

increased bone trabecula number

increased bone trabecular spacing

decreased trabecular bone mass

increased trabecular bone thickness

osteoporosis

increased bone mass

osteopetrosis

abnormal cartilage morphology

abnormal chondrocyte morphology

abnormal chondrocyte differentiation

abnormal bone ossification

decreased bone mineralization

increased bone mineralization

decreased bone resorption

increased bone resorption

decreased bone stiffness

decreased bone strength

fragile skeleton

Availability

Mouse Genotype

Tnfsf11^gum/Tnfsf11^gum

Tnfsf11^tles/Tnfsf11^tles

Tnfsf11^tm1.1Htaka/Tnfsf11^tm1.1Htaka

Tnfsf11^tm1.2Htaka/Tnfsf11^tm1.2Htaka

Tnfsf11^tm1Pngr/Tnfsf11^tm1Pngr

Tnfsf11^tm1Ywc/Tnfsf11^tm1Ywc

Tnfsf11^tles/Tnfsf11^tm1Pngr

Tnfsf11^tm1.2Htaka/Tnfsf11⁺

Tg(APCS-Tnfsf11*)#aKhs/0

Tg(APCS-Tnfsf11*)#bKhs/0

Tg(CAG-Tnfsf11*)#Khs/0

Tnfsf11^tm1.1Caob/Tnfsf11^tm1.1Caob
Tg(BGLAP-cre)1Clem/0 (conditional)

Tnfsf11^tm1.1Caob/Tnfsf11^tm1.1Caob
Tg(Dmp1-cre)1Jqfe/0 (conditional)

Tnfsf11^tm1.1Caob/Tnfsf11^tm1.1Caob
Tg(Prrx1-cre)1Cjt/0 (conditional)

Tnfsf11^tm1.1Caob/Tnfsf11^tm1.1Caob
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 (conditional)

Tnfsf11^tm1.1Caob/Tnfsf11^tm1.1Caob
Tg(Col10a1-cre)1427Vdm/0 (conditional)

Tnfsf11^tm1.1Htaka/Tnfsf11^tm1.2Htaka
Tg(Lck-cre)1Cwi/0 (conditional)

Tnfsf11^tm1.1Htaka/Tnfsf11^tm1.2Htaka
Tg(Dmp1-cre)1Jqfe/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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