Symbol
Name
ID

Tnfsf11
tumor necrosis factor (ligand) superfamily, member 11
MGI:1100089

Phenotype annotations related to craniofacial

Darker colors indicate more annotations

Human Phenotypes	Cranial hyperostosis	Mandibular osteomyelitis	Mandibular prognathia	Facial paralysis	Persistence of primary teeth	Carious teeth	Chronic rhinitis due to narrow nasal airway
Disease(s) Associated with TNFSF11
autosomal recessive osteopetrosis 2

Mouse Phenotypes

abnormal craniofacial bone morphology

abnormal cranial suture morphology

optic canal stenosis

decreased cranium height

small cranium

abnormal neurocranium morphology

thin neurocranium

abnormal hyoid bone body morphology

failure of tooth eruption

supernumerary teeth

mandible hypoplasia

abnormal zygomatic bone morphology

round face

Availability

Mouse Genotype

Tnfsf11^gum/Tnfsf11^gum

Tnfsf11^tles/Tnfsf11^tles

Tnfsf11^tm1.2Htaka/Tnfsf11^tm1.2Htaka

Tnfsf11^tm1Pngr/Tnfsf11^tm1Pngr

Tnfsf11^tm1Ywc/Tnfsf11^tm1Ywc

Tnfsf11^tles/Tnfsf11^tm1Pngr

Tnfsf11^tm1.1Caob/Tnfsf11^tm1.1Caob
Tg(BGLAP-cre)1Clem/0 (conditional)

Tnfsf11^tm1.1Caob/Tnfsf11^tm1.1Caob
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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