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Symbol
Name
ID 		Crebbp
CREB binding protein
MGI:1098280
Phenotype annotations related to craniofacial
!Indicates phenotype varies with strain background.
Darker colors indicate more annotations
Human Phenotypes
Abnormality of the hairline
Low anterior hairline
Low posterior hairline
Frontal bossing
Parietal foramina
Micrognathia
Retrognathia
Hypoplasia of the maxilla
Large foramen magnum
Microcephaly
Delayed cranial suture closure
Wide anterior fontanel
Facial grimacing
Abnormal facial shape
Facial hemangioma
Frontal hirsutism
Prominent forehead
Smooth philtrum
Thin upper lip vermilion
Cleft palate
High palate
High, narrow palate
Narrow palate
Narrow mouth
Abnormality of the dentition
Talon cusp
Enamel hypoplasia
Carious teeth
Dental crowding
Dental malocclusion
Increased overbite
Low hanging columella
Short columella
Convex nasal ridge
Wide nasal bridge
Deviated nasal septum
Prominent nose
Recurrent upper respiratory tract infections
Broad eyebrow
Highly arched eyebrow
Thick eyebrow
Long eyelashes
Downslanted palpebral fissures
Epicanthus
Telecanthus
Nasolacrimal duct obstruction
Disease(s) Associated with CREBBP
Rubinstein-Taybi syndrome

Mouse Phenotypes
abnormal craniofacial morphology
large anterior fontanelle
wide frontal bone
abnormal occipital bone morphology
supernumerary teeth
short premaxilla
maxilla hypoplasia
short maxilla
nasal bone hypoplasia
short nasal bone
cleft secondary palate
broad nasal bridge
flattened snout
short snout
Availability Mouse Genotype
Crebbptm2Pkb/Crebbptm2Pkb
CrebbpGt(U-San)112Imeg/Crebbp+
Crebbptm1Dli/Crebbp+
Crebbptm1Sis/Crebbp+ !
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory