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Symbol
Name
ID

Fxn
frataxin
MGI:1096879

Phenotype annotations related to homeostasis/metabolism

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Mitochondrial malic enzyme reduced	Decreased pyruvate carboxylase activity	Diabetes mellitus	Type II diabetes mellitus	Insulin resistance
Disease(s) Associated with FXN	Mitochondrial malic enzyme reduced	Decreased pyruvate carboxylase activity	Diabetes mellitus	Type II diabetes mellitus	Insulin resistance
Friedreich ataxia 1
type 2 diabetes mellitus

Mouse Phenotypes		homeostasis/metabolism phenotype	increased heart iron level	abnormal iron homeostasis	abnormal enzyme/coenzyme activity
Availability	Mouse Genotype	homeostasis/metabolism phenotype	increased heart iron level	abnormal iron homeostasis	abnormal enzyme/coenzyme activity
	Fxn^tm1Mkn/Fxn^tm1Mkn	*
	Gt(ROSA)26Sor^{tm1(H1/tetO-RNAi:Fxn)Dhg}/Gt(ROSA)26Sor⁺
	Fxn^tm2Mkn/Fxn^tm2.1Mkn Tg(Ckmm-cre)1Lrsn/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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