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Symbol
Name
ID

Fxn
frataxin
MGI:1096879

Phenotype annotations related to cellular

Darker colors indicate more annotations

Human Phenotypes	Mitochondrial malic enzyme reduced	Decreased pyruvate carboxylase activity
Disease(s) Associated with FXN	Mitochondrial malic enzyme reduced	Decreased pyruvate carboxylase activity
Friedreich ataxia 1

Mouse Phenotypes		abnormal myocardial fiber mitochondrial morphology	myocardium necrosis	abnormal mitochondrial morphology	disorganized mitochondrial cristae	increased mitochondrial size	dilated mitochondrion	increased embryonic tissue cell apoptosis	embryo tissue necrosis	abnormal respiratory electron transport chain	increased mitochondrial fission
Availability	Mouse Genotype	abnormal myocardial fiber mitochondrial morphology	myocardium necrosis	abnormal mitochondrial morphology	disorganized mitochondrial cristae	increased mitochondrial size	dilated mitochondrion	increased embryonic tissue cell apoptosis	embryo tissue necrosis	abnormal respiratory electron transport chain	increased mitochondrial fission
	Fxn^tm1Mkn/Fxn^tm1Mkn
	Gt(ROSA)26Sor^{tm1(H1/tetO-RNAi:Fxn)Dhg}/Gt(ROSA)26Sor⁺
	Fxn^tm2Mkn/Fxn^tm2.1Mkn Tg(Ckmm-cre)1Lrsn/0 (conditional)
	Fxn^tm2Mkn/Fxn^tm2.1Mkn Tg(Eno2-cre)39Jme/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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