Symbol
Name
ID

Hcn1
hyperpolarization activated cyclic nucleotide gated potassium channel 1
MGI:1096392

Phenotype annotations related to behavior/neurological

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Autistic behavior	Attention deficit hyperactivity disorder
Disease(s) Associated with HCN1	Autistic behavior	Attention deficit hyperactivity disorder
developmental and epileptic encephalopathy 24
generalized epilepsy with febrile seizures plus 10

Mouse Phenotypes

behavior/neurological phenotype

abnormal learning/memory/conditioning

abnormal eye blink conditioning behavior

abnormal motor learning

decreased exploration in new environment

abnormal spatial learning

abnormal depression-related behavior

increased thigmotaxis

tremors

abnormal locomotor behavior

abnormal gait

decreased locomotor activity

abnormal pain threshold

Availability

Mouse Genotype

Hcn1^em1(IMPC)H/Hcn1^em1(IMPC)H

Hcn1^tm1.1Lex/Hcn1^tm1.1Lex

Hcn1^tm2Kndl/Hcn1^tm2Kndl

Hcn1^tm1Kndl/Hcn1^tm1Kndl
Tg(Camk2a-cre)2Szi/? (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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