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Symbol
Name
ID
Pten
phosphatase and tensin homolog
MGI:109583
Phenotype annotations related to growth/size/body
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Splenomegaly
Hepatomegaly
Short stature
Tall stature
Overgrowth
Cachexia
Large for gestational age
Obesity
Disease(s) Associated with PTEN
Bannayan-Riley-Ruvalcaba syndrome
macrocephaly-autism syndrome

Mouse Phenotypes
decreased body fat mass
enlarged heart
cardiac hypertrophy
embryonic growth retardation
decreased embryo size
enlarged ovary
growth/size/body region phenotype
decreased body weight
slow postnatal weight gain
increased body weight
megacephaly
increased body length
decreased body size
postnatal growth retardation
pulmonary hyperplasia
enlarged liver
increased liver weight
enlarged spleen
increased spleen weight
spleen hyperplasia
Availability Mouse Genotype
Ptentm1.1Yxy/Ptentm1.1Yxy *
Ptentm1Engc/Ptentm1Engc
Ptentm1Mak/Ptentm1Mak
Ptentm1Engc/Pten+
Ptentm1Mak/Pten+
Ptentm1Rps/Pten+
Tg(Pten)1Srn/0
Ptentm1Hwu/Ptentm1Hwu
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Nes-cre)1Atp/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(GFAP-cre)25Mes/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Mx1-cre)1Cgn/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Gdf9-icre)5092Coo/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Cdh5-cre)7Mlia/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(CYP19A1-cre)1Jri/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Tyr-cre)1Lru/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Ddx4-cre)1Dcas/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Ddx4-cre/ERT2)1Dcas/0  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Ins2-cre)25Mgn/0  (conditional)
Gt(ROSA)26Sortm9(cre/ESR1)Arte/Gt(ROSA)26Sor+
Ptentm1Hwu/Ptentm1Hwu  (conditional)
Ptentm1Hwu/Ptentm1Hwu
Tg(Nkx2-1-cre)2Sand/0  (conditional)
Ptentm2Mak/Ptentm2Mak
Tg(Ckmm-cre)5Khn/0  (conditional)
Ptentm2Mak/Ptentm2Mak
Tg(Gfap-cre)1Sbk/0  (conditional)
Ptentm2Mak/Ptentm2Mak
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+  (conditional)
Ptentm2Mak/Ptentm2Mak
Tg(Cyp1a1-cre)1Dwi/0  (conditional)
Ptentm2Mak/Ptentm2Mak
Tg(Col2a1-cre)1Xya/?  (conditional)
Ptentm2Mak/Ptentm2Mak
Tg(SFTPC-rtTA)5Jaw/0
Tg(tetO-cre)1Jaw/0  (conditional)
Ptentm2Mak/Ptentm2Mak
Tg(Hoxb7-cre)5526Cmb/0  (conditional)
Ptentm2Mak/Ptentm2Mak
Tg(Eno2-cre)39Jme/0  (conditional)
Ptentm2Mak/Ptentm2Mak
Tg(Nes-cre/ERT2,-ALPP)1Sbk/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory