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Symbol
Name
ID

Dnm2
dynamin 2
MGI:109547

Phenotype annotations related to muscle

Darker colors indicate more annotations

Human Phenotypes

Facial palsy

Distal lower limb muscle weakness

Proximal upper limb amyotrophy

Proximal muscle weakness in upper limbs

Flexion contracture

Generalized hypotonia

EMG: positive sharp waves

EMG: myopathic abnormalities

EMG: myotonic discharges

Easy fatigability

Distal muscle weakness

Proximal muscle weakness

Type 1 muscle fiber predominance

Centrally nucleated skeletal muscle fibers

Distal amyotrophy

Proximal amyotrophy

Skeletal muscle hypertrophy

Disease(s) Associated with DNM2

centronuclear myopathy 1

Charcot-Marie-Tooth disease dominant intermediate B

Mouse Phenotypes

abnormal skeletal muscle fiber morphology

decreased skeletal muscle fiber size

decreased skeletal muscle fiber diameter

increased skeletal muscle fiber size

centrally nucleated skeletal muscle fibers

decreased skeletal muscle weight

abnormal skeletal muscle fiber type ratio

decreased skeletal muscle mass

increased skeletal muscle mass

muscular atrophy

abnormal muscle contractility

abnormal muscle electrophysiology

muscle weakness

myopathy

Availability

Mouse Genotype

Dnm2^tm1.1Ics/Dnm2^tm1.1Ics

Dnm2^tm4.1Ics/Dnm2^tm4.1Ics

Dnm2^tm1.1Ics/Dnm2⁺

Dnm2^tm2.1Ics/Dnm2⁺

Dnm2^tm4.1Ics/Dnm2⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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