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Symbol
Name
ID

Zic3
zinc finger protein of the cerebellum 3
MGI:106676

Phenotype annotations related to skeleton

Darker colors indicate more annotations

Human Phenotypes

Microcephaly

Hand polydactyly

Proximal placement of thumb

Absent radius

Short humerus

Congenital hip dislocation

Sacral dimple

Block vertebrae

Short long bone

Abnormality of the vertebral column

Absence of the sacrum

Abnormal vertebral morphology

Disease(s) Associated with ZIC3

situs inversus

visceral heterotaxy

X-linked VACTERL association

Mouse Phenotypes

increased cranium width

abnormal neurocranium morphology

abnormal interfrontal bone morphology

abnormal hyoid bone morphology

absent hyoid bone greater horns

abnormal jaw morphology

malocclusion

abnormal mandible morphology

mandibular coronoid process hypoplasia

premaxilla hypoplasia

maxilla hypoplasia

abnormal zygomatic bone morphology

cranioschisis

decreased caudal vertebrae number

abnormal cricoid cartilage morphology

abnormal axial skeleton morphology

abnormal rib morphology

decreased rib number

kyphosis

scoliosis

abnormal vertebrae morphology

vertebral transformation

Availability

Mouse Genotype

Zic3^Bn/Zic3^Bn

Zic3^tm1Bca/Zic3^tm1Bca

Zic3^tm1Jwb/Zic3^tm1Jwb

Zic3^Bn/Zic3⁺

Zic3^tm1Bca/Zic3⁺

Zic3^tm1Bca/Y

Zic3^tm1Jwb/Y

Zic3^tm2.1Jwb/Y
Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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