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Symbol
Name
ID
Zic3
zinc finger protein of the cerebellum 3
MGI:106676
Phenotype annotations related to embryo
Darker colors indicate more annotations
Human Phenotypes
Polyhydramnios
Absence of stomach bubble on fetal sonography
Disease(s) Associated with ZIC3
visceral heterotaxy
X-linked VACTERL association

Mouse Phenotypes
abnormal motile primary cilium morphology
abnormal embryo development
abnormal gastrulation
abnormal embryo turning
abnormal endoderm development
abnormal mesoderm development
abnormal left-right axis patterning
abnormal left-right axis symmetry of the somites
abnormal rostral-caudal axis patterning
caudal body truncation
rostral-caudal axis duplication
embryonic growth arrest
embryonic growth retardation
abnormal embryonic tissue morphology
abnormal embryonic epiblast morphology
abnormal egg cylinder morphology
abnormal neural plate morphology
abnormal neural tube morphology
abnormal embryonic neuroepithelial layer differentiation
delayed neural tube closure
open neural tube
split notochord
abnormal primitive streak morphology
abnormal anterior primitive streak morphology
abnormal primitive node morphology
absent primitive node
abnormal somite development
abnormal embryonic-extraembryonic boundary morphology
abnormal primitive streak elongation
abnormal extraembryonic tissue morphology
small allantois
abnormal anterior visceral endoderm morphology
Availability Mouse Genotype
Zic3Bn/Zic3Bn
Zic3Ka/Zic3Ka
Zic3tm1Bca/Zic3tm1Bca
Zic3tm1Jwb/Zic3tm1Jwb
Zic3tm1Bca/Zic3+
Zic3Ka/Y
Zic3tm1Bca/Y
Zic3tm1Jwb/Y
Zic3tm2.1Jwb/Y
Edil3Tg(Sox2-cre)1Amc/Edil3+  (conditional)
Zic3tm1.1Smwa/Y
Edil3Tg(Sox2-cre)1Amc/Edil3+  (conditional)
Zic3tm1.1Smwa/Y
Tg(T-cre)1Lwd/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory