|
Symbol Name ID |
Ptch1
patched 1 MGI:105373 |
| * | Aspects of the system are reported to show a normal phenotype. |
| ! | Indicates phenotype varies with strain background. |
| Darker colors indicate more annotations |
| Human Phenotypes | Odontogenic keratocysts of the jaw |
Cardiac fibroma |
Cardiac rhabdomyoma |
Hamartomatous stomach polyps |
Stomach cancer |
Ovarian carcinoma |
Ovarian fibroma |
Basal cell carcinoma |
Rhabdomyoma |
Meningioma |
Spinal cord tumor |
Medulloblastoma |
Neoplasm |
| Disease(s) Associated with PTCH1 | |||||||||||||
| holoprosencephaly | |||||||||||||
| nevoid basal cell carcinoma syndrome | |||||||||||||
| nevoid basal cell carcinoma syndrome 1 | |||||||||||||
| stomach cancer |
| Mouse Phenotypes | neoplasm |
increased gastrointestinal tumor incidence |
increased skin tumor incidence |
increased basal cell carcinoma incidence |
increased rhabdomyosarcoma incidence |
decreased tumor growth/size |
increased fibroma incidence |
increased lymphoma incidence |
increased medulloblastoma incidence |
increased hemangiosarcoma incidence |
increased incidence of tumors by UV-induction |
increased incidence of tumors by ionizing radiation induction |
increased tumor incidence |
|
| Availability | Mouse Genotype | |||||||||||||
| Ptch1tm1Cklr/Ptch1tm1Cklr | * | |||||||||||||
| Ptch1tm1.1Hahn/Ptch1+ | ||||||||||||||
| Ptch1tm1Mps/Ptch1+ | ||||||||||||||
| Ptch1tm1Mps/Ptch1+ Tg(Atoh1-GFP)1Jejo/? |
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| Ptch1tm1Zim/Ptch1+ | ! | |||||||||||||
| Ptch1tm1Bjw/Ptch1tm1Bjw Tg(Atoh1-cre)1Bfri/0 (conditional) |
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| Ptch1tm1Bjw/Ptch1tm1Bjw Tg(Atoh1-cre/Esr1*)14Fsh/0 (conditional) |
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| Ptch1tm1Bjw/Ptch1tm1Bjw Tg(GFAP-cre)25Mes/0 (conditional) |
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| Ptch1tm1Bjw/Ptch1tm1Bjw Tcf21tm1(cre)Seq/Tcf21+ (conditional) |
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| Ptch1tm1Bjw/Ptch1tm1Bjw Tg(KRT14-cre)8Brn/0 (conditional) |
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| Ptch1tm1Hahn/Ptch1tm1Hahn Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+ (conditional) |
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| Ptch1tm1Hahn/Ptch1+ Gt(ROSA)26Sortm2(cre/ERT2)Brn/Gt(ROSA)26Sor+ (conditional) |
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| Ptch1tm1Cklr/Ptch1+ Pax7tm1(cre)Mrc/Pax7+ (conditional) |
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| Ptch1tm1Yy/Ptch1+ Tg(BGLAP-cre)1Clem/0 (conditional) |
* | |||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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