|
Symbol Name ID |
Ube3a
ubiquitin protein ligase E3A MGI:105098 |
| * | Aspects of the system are reported to show a normal phenotype. |
| ! | Indicates phenotype varies with strain background. |
| Darker colors indicate more annotations |
| Human Phenotypes | Drooling |
Feeding difficulties in infancy |
Happy demeanor |
Paroxysmal bursts of laughter |
Hyperactivity |
| Disease(s) Associated with UBE3A | |||||
| Angelman syndrome |
| Mouse Phenotypes | behavior/neurological phenotype |
abnormal learning/memory/conditioning |
abnormal contextual conditioning behavior |
impaired contextual conditioning behavior |
abnormal operant conditioning behavior |
abnormal motor learning |
decreased exploration in new environment |
abnormal spatial learning |
decreased food intake |
abnormal emotion/affect behavior |
abnormal depression-related behavior |
decreased thigmotaxis |
abnormal motor capabilities/coordination/movement |
limb grasping |
impaired coordination |
abnormal posture |
abnormal gait |
decreased vertical activity |
increased vertical activity |
decreased locomotor activity |
increased locomotor activity |
hyperactivity |
bradykinesia |
abnormal sleep pattern |
abnormal nest building behavior |
decreased social investigation |
audiogenic seizures |
tonic-clonic seizures |
absence seizures |
abnormal spike wave discharge |
|
| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||
| Ube3aem1(IMPC)Hmgu/Ube3aem1(IMPC)Hmgu | |||||||||||||||||||||||||||||||
| Ube3aem1Mjz/Ube3aem1Mjz | * | ||||||||||||||||||||||||||||||
| Ube3atm1Alb/Ube3atm1Alb | ! | ||||||||||||||||||||||||||||||
| Ube3aem1(IMPC)Hmgu/Ube3a+ | |||||||||||||||||||||||||||||||
| Ube3aem1Mjz/Ube3a+ | * | ||||||||||||||||||||||||||||||
| Ube3atm1Alb/Ube3a+ | ! | ||||||||||||||||||||||||||||||
| Ube3atm1Jwf/Ube3a+ | |||||||||||||||||||||||||||||||
| Ube3atm1Yelg/Ube3a+ | |||||||||||||||||||||||||||||||
| Ube3atm1.1Bdph/Ube3a+ 7630403G23RikTg(Th-cre)1Tmd/7630403G23Rik+ (conditional) |
|||||||||||||||||||||||||||||||
| Tg(CAG-cre)13Miya/0 Ube3atm1Yelg/Ube3a+ (conditional) |
* | ||||||||||||||||||||||||||||||
| Tg(CAG-cre/Esr1*)5Amc/0 Ube3atm1Yelg/Ube3a+ (conditional) |
|||||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 04/16/2024 MGI 6.23 |
|
|
|
||
Analysis Tools