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Symbol
Name
ID

Gclc
glutamate-cysteine ligase, catalytic subunit
MGI:104990

Phenotype annotations related to homeostasis/metabolism

Darker colors indicate more annotations

Human Phenotypes	Reduced erythrocyte adenylate kinase activity	Reduced erythrocyte gamma-glutamyl cysteine synthetase activity	Hyperbilirubinemia	Elevated circulating hepatic transaminase concentration	Increased circulating lactate dehydrogenase concentration	Reduced circulating pyrimidine 5-prime-nucleotidase activity	Elevated sweat chloride	Dehydration	Hypercalciuria	Aminoaciduria	Hemoglobinuria
Disease(s) Associated with GCLC	Reduced erythrocyte adenylate kinase activity		Hyperbilirubinemia	Elevated circulating hepatic transaminase concentration	Increased circulating lactate dehydrogenase concentration		Elevated sweat chloride	Dehydration	Hypercalciuria	Aminoaciduria	Hemoglobinuria
cystic fibrosis
glutamate-cysteine ligase deficiency
hemolytic anemia

Mouse Phenotypes		abnormal homeostasis	increased circulating alanine transaminase level	increased circulating aspartate transaminase level
Availability	Mouse Genotype
	Gclc^tm1Tdal/Gclc^tm1Tdal Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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