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Symbol
Name
ID

Prkar1a
protein kinase, cAMP dependent regulatory, type I, alpha
MGI:104878

Phenotype annotations related to craniofacial

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Frontal bossing

Brachycephaly

Calvarial hyperostosis

Mandibular prognathia

Trismus

Hypoplasia of the maxilla

Paranasal sinus neoplasm

Malar flattening

Flat face

Moon facies

Round face

Midface retrusion

Prominent forehead

Abnormal hard palate morphology

Tongue nodules

Open mouth

Hypodontia

Delayed eruption of teeth

Dental malocclusion

Open bite

Palatine myxoma

Anteverted nares

Depressed nasal ridge

Broad nasal tip

Depressed nasal bridge

Wide nasal bridge

Short nose

Neoplasm of the pharynx

Epicanthus

Nodular changes affecting the eyelids

Telecanthus

Disease(s) Associated with PRKAR1A

acrodysostosis

Carney complex

primary pigmented nodular adrenocortical disease

Mouse Phenotypes		craniofacial phenotype	abnormal craniofacial morphology	abnormal craniofacial bone morphology	abnormal nose morphology	short snout	increased facial tumor incidence
Availability	Mouse Genotype	craniofacial phenotype	abnormal craniofacial morphology	abnormal craniofacial bone morphology	abnormal nose morphology	short snout	increased facial tumor incidence
	Prkar1a^tm1.1Geno/Prkar1a⁺
	Prkar1a^tm1.2Lsk/Prkar1a^tm1.2Lsk Tg(Tyr-cre)3Gfk/0 (conditional)
	Prkar1a^tm2Gsm/Prkar1a^tm2Gsm Tg(Plp1-cre)1Bzal/0 (conditional)
	Prkar1a^tm2Gsm/Prkar1a^tm2Gsm Tlx2^{tm1.1(cre)Rpk}/Tlx2⁺ (conditional)	*

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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