About   Help   FAQ
Symbol
Name
ID 		Tnf
tumor necrosis factor
MGI:104798
Phenotype annotations related to skeleton
!Indicates phenotype varies with strain background.
Darker colors indicate more annotations
Human Phenotypes
Joint hemorrhage
Abnormal skull morphology
Coronal craniosynostosis
Decreased calvarial ossification
Abnormal facial skeleton morphology
Micrognathia
Sinusitis
Chronic sinusitis
Malar flattening
Interphalangeal joint erosions
Clubbing of fingers
Swan neck-like deformities of the fingers
Brachydactyly
Joint swelling
Aortic valve calcification
Mitral valve calcification
Osteomyelitis
Arthrogryposis multiplex congenita
Joint stiffness
Delayed skeletal maturation
Avascular necrosis
Bone pain
Pathologic fracture
Recurrent fractures
Abnormality of the skeletal system
Bent long bone
Hypoplastic pubic bone
Short clavicles
Bell-shaped thorax
Vertebral compression fracture
Abnormal bone structure
Increased bone mineral density
Reduced bone mineral density
Osteopenia
Osteoporosis
Osteolysis
Arthritis
Gout
Osteoarthritis
Rheumatoid arthritis
Polyarticular arthritis
Joint dislocation
Digital flexor tenosynovitis
Disease(s) Associated with TNF
Behcet's disease
beta thalassemia
coronary artery disease
cystic fibrosis
Gaucher's disease
leprosy
multiple myeloma
pre-eclampsia
rheumatoid arthritis
Sjogren's syndrome
systemic lupus erythematosus
thrombocytopenia

Mouse Phenotypes
alveolar process atrophy
accelerated temporomandibular joint osteoarthritis
decreased susceptibility to induced arthritis
rheumatoid arthritis
arthritis
abnormal wrist joint morphology
long tibia
abnormal rib joint morphology
abnormal thoracic vertebrae morphology
abnormal spine curvature
kyphosis
increased bone mineral density
increased osteoblast cell number
abnormal trabecular bone morphology
abnormal joint morphology
joint dislocation
Availability Mouse Genotype
Lta/Tnftm1Eug/Lta/Tnftm1Eug
TnfBpsm1/TnfBpsm1
Tnftm1Gkl/Tnftm1Gkl
Tnftm2Gkl/Tnftm2Gkl
TnfBpsm1/Tnf+
Tnfem4Boui/Tnf+
Tnftm1Gkl/Tnftm2Gkl
Tnftm2Gkl/Tnf+ !
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory