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Symbol
Name
ID
Tnf
tumor necrosis factor
MGI:104798
Phenotype annotations related to homeostasis/metabolism
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Increased circulating IgA level
Increased circulating IgE level
Increased circulating IgG level
Polyclonal elevation of IgM
Decreased circulating antibody level
Increased circulating antibody level
Paraproteinemia
Abnormality of metabolism/homeostasis
Hypercalcemia
Abnormality of iron homeostasis
Increased circulating iron concentration
Elevated transferrin saturation
Decreased level of 1,5 anhydroglucitol in serum
Hyperbilirubinemia
Decreased HDL cholesterol concentration
Increased LDL cholesterol concentration
Hypercholesterolemia
Hypertriglyceridemia
Elevated circulating creatinine concentration
Elevated circulating C-reactive protein concentration
Increased circulating ferritin concentration
Hyperproteinemia
Elevated circulating hepatic transaminase concentration
Elevated erythrocyte sedimentation rate
Hyperglycemia
Hypoglycemia
Glucose intolerance
Diabetes mellitus
Type I diabetes mellitus
Type II diabetes mellitus
Impaired glucose tolerance
Elevated sweat chloride
Ketoacidosis
Dehydration
Edema
Hydrops fetalis
Nonimmune hydrops fetalis
Joint swelling
Pleural effusion
Pulmonary edema
Abnormality of temperature regulation
Fever
Food intolerance
Abnormality of vitamin B12 metabolism
Elevated hepatic iron concentration
Hypercalciuria
Hematuria
Pyuria
Decreased level of D-mannose in urine
Proteinuria
Amyloidosis
Aortic valve calcification
Mitral valve calcification
Increased circulating free T3
Increased circulating free T4 concentration
Decreased thyroid-stimulating hormone level
Atypical scarring of skin
Disease(s) Associated with TNF
atopic dermatitis
Behcet's disease
beta thalassemia
coronary artery disease
cystic fibrosis
Gaucher's disease
Graves' disease
hemochromatosis
hidradenitis suppurativa
hypochromic microcytic anemia
malaria
multiple myeloma
pre-eclampsia
rheumatoid arthritis
Sjogren's syndrome
systemic lupus erythematosus
thrombocytopenia
type 1 diabetes mellitus

Mouse Phenotypes
homeostasis/metabolism phenotype
steatorrhea
decreased susceptibility to diet-induced obesity
increased susceptibility to diet-induced obesity
decreased circulating glucose level
decreased circulating insulin level
abnormal circulating leptin level
decreased circulating leptin level
decreased circulating triglyceride level
abnormal circulating chemokine level
decreased circulating interferon-gamma level
decreased circulating interleukin-1 alpha level
decreased circulating interleukin-1 beta level
decreased circulating interleukin-6 level
decreased circulating tumor necrosis factor level
increased circulating tumor necrosis factor level
abnormal blood coagulation
abnormal atrial thrombosis
cyanosis
abnormal glucose homeostasis
increased hyaluronic acid level
increased serotonin level
abnormal lipid homeostasis
decreased liver free fatty acids level
increased collagen level
abnormal cytokine level
decreased incidence of tumors by chemical induction
enhanced wound healing
increased susceptibility to injury
Availability Mouse Genotype
Lta/Tnftm1Eug/Lta/Tnftm1Eug
TnfBpsm1/TnfBpsm1
Tnftm1Gkl/Tnftm1Gkl
Tnftm1Jods/Tnftm1Jods
Tnftm1Ljo/Tnftm1Ljo
Tnftm1Sek/Tnftm1Sek
Tnftm2Gkl/Tnftm2Gkl
Tnftm2Jods/Tnftm2Jods
Tnftm3Gkl/Tnftm3Gkl
TnfBpsm1/Tnf+
Tnftm1Gkl/Tnftm2Gkl
Tnftm2Gkl/Tnf+
Tg(Ins2-Tnf)17Flv/0 *
Tg(SFTPC-Tnf)2Pva/0
Tg(Myh6-Tnf)1Brgi/?
Tg(Myh6-Tnf)2Brgi/?
Tnftm1.1Sned/Tnftm1.1Sned
Lyz2tm1(cre)Ifo/Lyz2+  (conditional)
Tnftm1.1Sned/Tnftm1.1Sned
Tg(Cd4-cre)1Cwi/0  (conditional)
Tnftm2.1Gkl/Tnftm2.1Gkl
Tg(Fabp1-cre)1Jig/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory