Symbol
Name
ID

Myo7a
myosin VIIA
MGI:104510

Phenotype annotations related to hearing/vestibular/ear

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Abnormal cochlea morphology	Abnormal vestibular function	Vestibular areflexia	Vertigo	Vestibular hypofunction	Absent vestibular function	Sensorineural hearing impairment	Bilateral sensorineural hearing impairment	Hearing impairment	Tinnitus
Disease(s) Associated with MYO7A	Abnormal cochlea morphology	Abnormal vestibular function	Vestibular areflexia	Vertigo	Vestibular hypofunction	Absent vestibular function	Sensorineural hearing impairment	Bilateral sensorineural hearing impairment	Hearing impairment	Tinnitus
autosomal dominant nonsyndromic deafness 11
autosomal recessive nonsyndromic deafness 2
Leber congenital amaurosis
Usher syndrome
Usher syndrome type 1

Mouse Phenotypes

hearing/vestibular/ear phenotype

abnormal cochlear basement membrane morphology

abnormal cochlear hair cell morphology

decreased cochlear outer hair cell number

abnormal cochlear hair cell stereociliary bundle morphology

abnormal cochlear hair cell inter-stereocilial links morphology

absent cochlear hair bundle ankle links

abnormal inner hair cell stereociliary bundle morphology

abnormal orientation of inner hair cell stereociliary bundles

decreased inner hair cell stereocilia number

fused inner hair cell stereocilia

abnormal orientation of cochlear hair cell stereociliary bundles

abnormal orientation of outer hair cell stereociliary bundles

abnormal outer hair cell stereociliary bundle morphology

decreased outer hair cell stereocilia number

short cochlear hair cell stereocilia

abnormal cochlear outer hair cell morphology

abnormal cochlear OHC efferent innervation pattern

cochlear outer hair cell degeneration

short cochlear outer hair cells

cochlear hair cell degeneration

abnormal organ of Corti morphology

stria vascularis degeneration

thin stria vascularis

cochlear degeneration

abnormal hair cell morphology

abnormal vestibular hair cell stereociliary bundle morphology

decreased vestibular hair cell stereocilia number

abnormal inner ear vestibule morphology

vestibular saccular macula degeneration

abnormal ear physiology

absent cochlear microphonics

abnormal hearing physiology

increased or absent threshold for auditory brainstem response

abnormal auditory summating potential

abnormal cochlear nerve compound action potential

increased cochlear nerve compound action potential

absent distortion product otoacoustic emissions

increased susceptibility to age-related hearing loss

impaired hearing

deafness

sensorineural hearing loss

absent linear vestibular evoked potential

Availability

Mouse Genotype

Myo7a^26SB/Myo7a^26SB

Myo7a^816SB/Myo7a^816SB

Myo7a^3336SB/Myo7a^3336SB

Myo7a^4494SB/Myo7a^4494SB

Myo7a^4626SB/Myo7a^4626SB

Myo7a^dmbo2/Myo7a^dmbo2

Myo7a^ewaso/Myo7a^ewaso

Myo7a^Hdb/Myo7a^Hdb

Myo7a^mpc142H/Myo7a^mpc142H

Myo7a^polka/Myo7a^polka

Myo7a^sh1-6J/Myo7a^sh1-6J

Myo7a^sh1-7J/Myo7a^sh1-7J

Myo7a^sh1-8J/Myo7a^sh1-8J

Myo7a^sh1-9J/Myo7a^sh1-9J

Myo7a^sh1/Myo7a^sh1

Myo7a^{tm1b(EUCOMM)Wtsi}/Myo7a^{tm1b(EUCOMM)Wtsi}

Myo7a^4626SB/Myo7a⁺

Myo7a^ewaso/Myo7a⁺

Myo7a^Hdb/Myo7a^4626SB

Myo7a^Hdb/Myo7a⁺

Myo7a^sh1-8J/Myo7a⁺

Myo7a^{tm1b(EUCOMM)Wtsi}/Myo7a⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23