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Symbol
Name
ID

Spr
sepiapterin reductase
MGI:103078

Phenotype annotations related to homeostasis/metabolism

Darker colors indicate more annotations

Human Phenotypes	Hyperphenylalaninemia	Transient hyperphenylalaninemia	Abnormal circulating biopterin concentration	Abnormal circulating neopterin concentration	Reduced sepiapterin reductase activity in cultured fibroblasts	Temperature instability
Disease(s) Associated with SPR
sepiapterin reductase deficiency

Mouse Phenotypes		increased circulating phenylalanine level	decreased phenylalanine level	decreased circulating insulin-like growth factor I level	decreased dopamine level	decreased noradrenaline level	abnormal enzyme/coenzyme level	abnormal biopterin level	abnormal neopterin level	decreased serotonin level
Availability	Mouse Genotype	increased circulating phenylalanine level	decreased phenylalanine level	decreased circulating insulin-like growth factor I level	decreased dopamine level	decreased noradrenaline level	abnormal enzyme/coenzyme level	abnormal biopterin level	abnormal neopterin level	decreased serotonin level
	Spr^tm1Lex/Spr^tm1Lex
	Spr^tm1Spo/Spr^tm1Spo

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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