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Symbol
Name
ID

Pdx1
pancreatic and duodenal homeobox 1
MGI:102851

Phenotype annotations related to homeostasis/metabolism

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Reduced C-peptide level	Neonatal insulin-dependent diabetes mellitus	Maturity-onset diabetes of the young	Type II diabetes mellitus	Insulin resistance
Disease(s) Associated with PDX1	Reduced C-peptide level	Neonatal insulin-dependent diabetes mellitus	Maturity-onset diabetes of the young	Type II diabetes mellitus	Insulin resistance
maturity-onset diabetes of the young type 4
pancreatic agenesis
type 2 diabetes mellitus

Mouse Phenotypes		homeostasis/metabolism phenotype	increased glucagon secretion	decreased insulin secretion	increased circulating glucose level	hyperglycemia	decreased circulating insulin level	dehydration	impaired glucose tolerance	increased urine glucose level
Availability	Mouse Genotype	homeostasis/metabolism phenotype	increased glucagon secretion	decreased insulin secretion	increased circulating glucose level	hyperglycemia	decreased circulating insulin level	dehydration	impaired glucose tolerance	increased urine glucose level
	Pdx1^tm1.1Stof/Pdx1^tm1.1Stof
	Pdx1^tm1Cvw/Pdx1^tm1Cvw
	Pdx1^tm1Ted/Pdx1^tm1Ted
	Pdx1^tm2Cvw/Pdx1^tm2Cvw
	Pdx1^tm1.1Stof/Pdx1⁺
	Pdx1^{tm1b(EUCOMM)Wtsi}/Pdx1⁺
	Pdx1^tm1Cvw/Pdx1⁺
	Pdx1^tm1Cvw/Pdx1^tm1.1Stof
	Pdx1^tm1Macd/Pdx1⁺
	Pdx1^tm1Ted/Pdx1⁺
	Pdx1^tm2Cvw/Pdx1⁺	*
	Pdx1^tm2Cvw/Pdx1^tm3Cvw
	Pdx1^tm3Cvw/Pdx1⁺
	Pdx1^tm1Heed/Pdx1^tm1Heed Tg(Ins2-cre)1Heed/0 (conditional)
	Pdx1^tm1Cvw/Pdx1^tm4Cvw Tg(Ins2-cre)25Mgn/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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