|
Symbol Name ID |
Six3
sine oculis-related homeobox 3 MGI:102764 |
| Darker colors indicate more annotations |
| Human Phenotypes | Abnormal skull morphology |
Frontal bossing |
Flat occiput |
Aplasia of the premaxilla |
Hypoplasia of the zygomatic bone |
Malar flattening |
Dandy-Walker malformation |
Microcephaly |
Macrocephaly |
Encephalocele |
Abnormal facial shape |
Midface retrusion |
Broad philtrum |
Deep philtrum |
Median cleft upper lip |
Bilateral cleft lip |
Submucous cleft hard palate |
Bifid uvula |
Median cleft palate |
Bilateral cleft palate |
Solitary median maxillary central incisor |
Tooth agenesis |
Choanal atresia |
Anteverted nares |
Depressed nasal ridge |
Depressed nasal tip |
Absent nasal septal cartilage |
Aplasia of the nasal bone |
Absent nares |
Aplasia/Hypoplasia involving the nose |
Proboscis |
Anosmia |
Hyposmia |
Highly arched eyebrow |
Synophrys |
Thick eyebrow |
Blepharophimosis |
Upslanted palpebral fissure |
Epicanthus |
| Disease(s) Associated with SIX3 | |||||||||||||||||||||||||||||||||||||||
| holoprosencephaly | |||||||||||||||||||||||||||||||||||||||
| holoprosencephaly 2 |
| Mouse Phenotypes | abnormal craniofacial morphology |
abnormal cranium morphology |
absent nasal placodes |
absent optic pit |
|
| Availability | Mouse Genotype | ||||
| Six3tm1Gco/Six3tm1Gco | |||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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