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Symbol
Name
ID
Nrl
neural retina leucine zipper gene
MGI:102567
Phenotype annotations related to vision/eye
Darker colors indicate more annotations
Human Phenotypes
Macular edema
Chorioretinal atrophy
Peripapillary chorioretinal atrophy
Macular atrophy
Rod-cone dystrophy
Undetectable electroretinogram
Nyctalopia
Visual impairment
Blindness
Disease(s) Associated with NRL
retinitis pigmentosa 27

Mouse Phenotypes
absent retinal rod cells
increased retinal cone cell number
abnormal retinal photoreceptor morphology
abnormal photoreceptor outer segment morphology
short photoreceptor outer segment
abnormal retinal cone cell morphology
retinal cone cell degeneration
retinal photoreceptor degeneration
abnormal retinal pigment epithelium morphology
abnormal retina morphology
abnormal retinal outer nuclear layer morphology
abnormal eye physiology
abnormal electroretinogram waveform feature
abnormal cone electrophysiology
abnormal rod electrophysiology
Availability Mouse Genotype
Nrltm1.1(Thrb)Df/Nrltm1.1(Thrb)Df
Nrltm1.1Jcco/Nrltm1.1Jcco
Nrltm1Asw/Nrltm1Asw
Nrltm1Jcco/Nrltm1Jcco
Tg(CAG-cre/Esr1*)5Amc/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/14/2020
MGI 6.14
The Jackson Laboratory