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Symbol
Name
ID 		Nrl
neural retina leucine zipper gene
MGI:102567
Phenotype annotations related to vision/eye
Darker colors indicate more annotations
Human Phenotypes
Macular edema
Abnormal retinal vascular morphology
Attenuation of retinal blood vessels
Keratoconus
Posterior subcapsular cataract
Chorioretinal atrophy
Peripapillary chorioretinal atrophy
Optic atrophy
Optic disc pallor
Macular atrophy
Abnormality of retinal pigmentation
Bone spicule pigmentation of the retina
Retinal degeneration
Rod-cone dystrophy
Abnormal electroretinogram
Undetectable electroretinogram
Nystagmus
Ophthalmoplegia
Nyctalopia
Progressive night blindness
Photophobia
Photopsia
Visual impairment
Reduced visual acuity
Blindness
Constriction of peripheral visual field
Peripheral visual field loss
Glaucoma
Disease(s) Associated with NRL
retinitis pigmentosa
retinitis pigmentosa 27

Mouse Phenotypes
absent retina rod cells
increased retina cone cell number
abnormal retina photoreceptor morphology
abnormal photoreceptor outer segment morphology
short photoreceptor outer segment
abnormal retina cone cell morphology
retina cone cell degeneration
retina photoreceptor degeneration
abnormal retina pigment epithelium morphology
abnormal retina morphology
abnormal retina outer nuclear layer morphology
abnormal eye physiology
abnormal electroretinogram waveform feature
abnormal cone electrophysiology
abnormal rod electrophysiology
Availability Mouse Genotype
Nrltm1.1(Thrb)Df/Nrltm1.1(Thrb)Df
Nrltm1.1Jcco/Nrltm1.1Jcco
Nrltm1Asw/Nrltm1Asw
Nrltm1Jcco/Nrltm1Jcco
Tg(CAG-cre/Esr1*)5Amc/0  (conditional)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory