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Symbol
Name
ID
Dlx5
distal-less homeobox 5
MGI:101926
Phenotype annotations related to hearing/vestibular/ear
Darker colors indicate more annotations
Human Phenotypes
Sensorineural hearing impairment
Disease(s) Associated with DLX5
split hand-foot malformation 1 with sensorineural hearing loss

Mouse Phenotypes
abnormal stapedial artery morphology
abnormal middle ear ossicle morphology
abnormal gonial bone morphology
abnormal malleus morphology
small malleus processus brevis
absent stapes
abnormal outer ear morphology
abnormal external auditory canal morphology
abnormal outer ear cartilage morphology
otic vesicle hypoplasia
abnormal cochlea morphology
abnormal scala vestibuli morphology
decreased cochlear coiling
abnormal semicircular canal morphology
decreased lateral semicircular canal size
absent posterior semicircular canal
abnormal crista ampullaris morphology
abnormal crista ampullaris neuroepithelium morphology
absent superior semicircular canal
absent semicircular canals
abnormal inner ear vestibule morphology
abnormal utricular macula morphology
enlarged utricle
abnormal vestibular saccule morphology
abnormal vestibular saccular macula morphology
absent endolymphatic duct
short endolymphatic duct
abnormal otic capsule morphology
otic capsule hypoplasia
abnormal middle ear morphology
abnormal epitympanic recess morphology
abnormal tegmen tympani morphology
decreased tympanic ring size
Availability Mouse Genotype
Dlx5/Dlx6tm1Levi/Dlx5/Dlx6tm1Levi
Dlx5tm1Jlr/Dlx5tm1Jlr
Dlx5tm1Levi/Dlx5tm1Levi

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory