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Symbol
Name
ID
Pou3f4
POU domain, class 3, transcription factor 4
MGI:101894
Phenotype annotations related to hearing/vestibular/ear
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Progressive sensorineural hearing impairment
Dilatated internal auditory canal
Conductive hearing impairment
Stapes ankylosis
Disease(s) Associated with POU3F4
sensorineural hearing loss

Mouse Phenotypes
hearing/vestibular/ear phenotype
abnormal internal auditory canal morphology
abnormal bony labyrinth
abnormal oval window morphology
abnormal stapes morphology
abnormal stapes crus morpholgy
abnormal stapes footplate morphology
abnormal cochlea morphology
abnormal Reissner membrane morphology
detached Reissner membrane
distended Reissner membrane
cochlear outer hair cell degeneration
abnormal spiral ligament fibrocyte morphology
abnormal type I spiral ligament fibrocytes
abnormal type II spiral ligament fibrocytes
abnormal stria vascularis morphology
abnormal scala tympani morphology
small scala tympani
abnormal spiral limbus morphology
decreased cochlear coiling
abnormal lateral semicircular canal morphology
abnormal superior semicircular canal morphology
dilated endolymphatic duct
decreased endocochlear potential
increased or absent threshold for auditory brainstem response
impaired hearing
conductive hearing loss
deafness
sensorineural hearing loss
abnormal vestibular system physiology
absent linear vestibular evoked potential
Availability Mouse Genotype
Pou3f4del-J/Pou3f4del-J
Pou3f4sdl/Pou3f4sdl *
Pou3f4Slf/Pou3f4Slf
Pou3f4tm1Tno/Pou3f4tm1Tno
Pou3f4del-J/Pou3f4+
Pou3f4tm1Tno/Pou3f4+
Pou3f4del-J/Y
Pou3f4sdl/Y
Pou3f4Slf/Y
Pou3f4tm1Cren/Y
Pou3f4tm1Tno/Y

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory