Symbol Name ID |
Myo7a
myosin VIIA MGI:104510 |
* | Aspects of the system are reported to show a normal phenotype. |
Darker colors indicate more annotations |
Human Phenotypes | Abnormal cochlea morphology |
Abnormal vestibular function |
Vestibular areflexia |
Vertigo |
Vestibular hypofunction |
Absent vestibular function |
Sensorineural hearing impairment |
Bilateral sensorineural hearing impairment |
Hearing impairment |
Tinnitus |
Disease(s) Associated with MYO7A | ||||||||||
autosomal dominant nonsyndromic deafness 11 | ||||||||||
autosomal recessive nonsyndromic deafness 2 | ||||||||||
Leber congenital amaurosis | ||||||||||
Usher syndrome | ||||||||||
Usher syndrome type 1 |
Mouse Phenotypes | hearing/vestibular/ear phenotype |
abnormal cochlear basement membrane morphology |
abnormal cochlear hair cell morphology |
decreased cochlear outer hair cell number |
abnormal cochlear hair cell stereociliary bundle morphology |
abnormal cochlear hair cell inter-stereocilial links morphology |
absent cochlear hair bundle ankle links |
abnormal inner hair cell stereociliary bundle morphology |
abnormal orientation of inner hair cell stereociliary bundles |
decreased inner hair cell stereocilia number |
fused inner hair cell stereocilia |
abnormal orientation of cochlear hair cell stereociliary bundles |
abnormal orientation of outer hair cell stereociliary bundles |
abnormal outer hair cell stereociliary bundle morphology |
decreased outer hair cell stereocilia number |
short cochlear hair cell stereocilia |
abnormal cochlear outer hair cell morphology |
abnormal cochlear OHC efferent innervation pattern |
cochlear outer hair cell degeneration |
short cochlear outer hair cells |
cochlear hair cell degeneration |
abnormal organ of Corti morphology |
stria vascularis degeneration |
thin stria vascularis |
cochlear degeneration |
abnormal hair cell morphology |
abnormal vestibular hair cell stereociliary bundle morphology |
decreased vestibular hair cell stereocilia number |
abnormal inner ear vestibule morphology |
vestibular saccular macula degeneration |
abnormal ear physiology |
absent cochlear microphonics |
abnormal hearing physiology |
increased or absent threshold for auditory brainstem response |
abnormal auditory summating potential |
abnormal cochlear nerve compound action potential |
increased cochlear nerve compound action potential |
absent distortion product otoacoustic emissions |
increased susceptibility to age-related hearing loss |
impaired hearing |
deafness |
sensorineural hearing loss |
absent linear vestibular evoked potential |
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Availability | Mouse Genotype | |||||||||||||||||||||||||||||||||||||||||||
Myo7a26SB/Myo7a26SB | ||||||||||||||||||||||||||||||||||||||||||||
Myo7a816SB/Myo7a816SB | ||||||||||||||||||||||||||||||||||||||||||||
Myo7a3336SB/Myo7a3336SB | ||||||||||||||||||||||||||||||||||||||||||||
Myo7a4494SB/Myo7a4494SB | ||||||||||||||||||||||||||||||||||||||||||||
Myo7a4626SB/Myo7a4626SB | ||||||||||||||||||||||||||||||||||||||||||||
Myo7admbo2/Myo7admbo2 | * | |||||||||||||||||||||||||||||||||||||||||||
Myo7aewaso/Myo7aewaso | * | |||||||||||||||||||||||||||||||||||||||||||
Myo7aHdb/Myo7aHdb | ||||||||||||||||||||||||||||||||||||||||||||
Myo7ampc142H/Myo7ampc142H | ||||||||||||||||||||||||||||||||||||||||||||
Myo7apolka/Myo7apolka | ||||||||||||||||||||||||||||||||||||||||||||
Myo7ash1-6J/Myo7ash1-6J | ||||||||||||||||||||||||||||||||||||||||||||
Myo7ash1-7J/Myo7ash1-7J | ||||||||||||||||||||||||||||||||||||||||||||
Myo7ash1-8J/Myo7ash1-8J | ||||||||||||||||||||||||||||||||||||||||||||
Myo7ash1-9J/Myo7ash1-9J | ||||||||||||||||||||||||||||||||||||||||||||
Myo7ash1/Myo7ash1 | ||||||||||||||||||||||||||||||||||||||||||||
Myo7atm1b(EUCOMM)Wtsi/Myo7atm1b(EUCOMM)Wtsi | ||||||||||||||||||||||||||||||||||||||||||||
Myo7a4626SB/Myo7a+ | ||||||||||||||||||||||||||||||||||||||||||||
Myo7aewaso/Myo7a+ | ||||||||||||||||||||||||||||||||||||||||||||
Myo7aHdb/Myo7a4626SB | ||||||||||||||||||||||||||||||||||||||||||||
Myo7aHdb/Myo7a+ | ||||||||||||||||||||||||||||||||||||||||||||
Myo7ash1-8J/Myo7a+ | ||||||||||||||||||||||||||||||||||||||||||||
Myo7atm1b(EUCOMM)Wtsi/Myo7a+ |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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