Analysis Tools
behavior/neurological
| N |
• generally normal
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• withdrawl latencies and frequencies in von Frey and high intensity radiant heat tests were similar to controls
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• complete Freund's reagent failed to cause hyppersensitivity to mechanical pain stimuli
• only modest increases in response to mechanical stimulus after 5th lumbar nerve transection and no increase in contralateral withdrawal frequencies
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nervous system
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• gossly normal
(J:68924)
• surface expression of NR2A and NR2B N-methyl-D-aspartate (NMDA) receptors is reduced by 64 and 50% respectively on cultured spinal dorsal horn neurons and on the spinal cord itself
(J:84686)
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• reduced or absent EPSC responses related to NMDA receptors in dorsal horn neurons
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• reduced or absent EPSP responses related to NMDA receptors in dorsal horn neurons
• fEPSP related to NMPA receptors in various regions of the forebrain also reduced or absent
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