nephrotic syndrome Disease Ontology Browser

Disease Ontology Browser

nephrotic syndrome (DOID:1184)
Alliance: disease page
Alt IDs: ICD10CM:N04, ICD9CM:581, MESH:D009404, NCI:C34845, UMLS_CUI:C0027726
Definition: A nephrosis characterized by marked increase in glomerular protein permeability resulting in marked elevation of urine protein levels, hypoalbuminemia, hyperlipidemia, and hypercoagulability.

Term Browser
Genes (38)
Models (13)

Disease References using Mouse Models (13)

Mouse Models

Human Disease Modeled: nephrotic syndrome
Associated Mouse Gene: Arhgdia

Allelic Composition	Genetic Background	Reference	Phenotypes
Arhgdiatm1Ytk/Arhgdiatm1Ytk	involves: 129S/SvEv * C57BL/6 * DBA	J:57995	View

Mouse Models

Human Disease Modeled: nephrotic syndrome
Associated Mouse Gene: Fat1

Allelic Composition	Genetic Background	Reference	Phenotypes
Fat1tm1.1Nsib/Fat1tm1.1Nsib Tg(NPHS2-cre)295Lbh/0	involves: 129/Sv * 129S4/SvJaeSor * C57BL/6 * C57BL/6J * SJL	J:234732	View

Mouse Models

Human Disease Modeled: nephrotic syndrome
Associated Mouse Gene: Itsn2

Allelic Composition	Genetic Background	Reference	Phenotypes
Itsn2tm1Kure/Itsn2tm1Kure	involves: C57BL/6	J:262845	View

Mouse Models

Human Disease Modeled: nephrotic syndrome
Associated Mouse Gene: Mpv17

Allelic Composition	Genetic Background	Reference	Phenotypes
Mpv17/Mpv17	CFW-Mpv17/J	J:10661, J:108252	View

Mouse Models

Human Disease Modeled: nephrotic syndrome
Associated Mouse Gene: Nphs1

Allelic Composition	Genetic Background	Reference	Phenotypes
Nphs1Gt(pT1Betageo)1Ruiz/Nphs1Gt(pT1Betageo)1Ruiz	involves: 129P2/OlaHsd * C57BL/6	J:86048	View
Nphs1tm1Rkl/Nphs1tm1Rkl	involves: 129S2/SvPasCrl	J:78616	View
Nphs1Gt(pT1Betageo)1Ruiz/Nphs1+	involves: 129P2/OlaHsd * C57BL/6	J:86048	View
Nphs1tm1Ktry/Nphs1tm1Ktry	involves: 129X1/SvJ * C57BL/6	J:66970	View

Mouse Models

Human Disease Modeled: nephrotic syndrome
Associated Mouse Gene: Nphs2

Allelic Composition	Genetic Background	Reference	Phenotypes
Nphs2tm1Antc/Nphs2tm1Antc	129-Nphs2^tm1Antc	J:87577	View
Nphs2tm1Antc/Nphs2tm1Antc	involves: 129 * C57BL/6J	J:87577	View
Nphs2tm1Antc/Nphs2tm3.1Antc Tg(CAG-cre/Esr1*)86Lbgn/0	involves: 129 * C57BL/6 * DBA	J:166320	View
Nphs2tm2.1Antc/Nphs2tm3.1Antc Tg(CAG-cre/Esr1*)86Lbgn/0	involves: 129S2/SvPas * C57BL/6 * DBA	J:245693	View

Mouse Models

Human Disease Modeled: nephrotic syndrome

Allelic Composition	Genetic Background	Reference	Phenotypes
Hprt1tm1(Nphs1-CMIP)Dsah/Hprt1+	B6.Cg-Hprt1^{tm1(Nphs1-CMIP)Dsah}	J:185411	View

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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