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Gene Expression Data
Assay Details
Assay
Reference: J:135527 Lehtonen S, et al., CD2-associated protein is widely expressed and differentially regulated during embryonic development. Differentiation. 2008 May;76(5):506-17
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6515611
Gene symbol: Cd2ap
Gene name: CD2-associated protein
Antibody: CD2AP antibody (R1774)
Detection system: Secondary antibody coupled to horseradish peroxidase
Assay notes: It was not specified which antibody was used, although it was mentioned that all three antisera gave similar staining patterns.
Results
Specimen 3A embryo: embryonic day 6.0 (more )
Structure Level Pattern Image Note
TS8: epiblast Weak Regionally restricted 3A Expressed in the cytoplasm of the primitive ectoderm cells surrounding the proamniotic cavity.

Specimen 3A decidua: postnatal adult (more )
Note: Day 6 of pregnancy.
Structure Level Pattern Image Note
TS28: decidua Strong 3A

Specimen 3B embryo: embryonic day 7.0 (more )
Structure Level Pattern Image Note
TS10: embryo ectoderm Weak 3B
TS10: embryo endoderm Weak 3B
TS10: embryo mesoderm Weak 3B

Specimen 3B decidua: postnatal adult (more )
Note: Day 7 of pregnancy.
Structure Level Pattern Image Note
TS28: decidua Strong 3B

Specimen 3C: embryonic day 11.0 (more )
Structure Level Pattern Image Note
TS18: trophoblast giant cell Weak 3C
TS18: labyrinthine zone Present Regionally restricted 3C Expressed in the endothelium.
TS18: spongiotrophoblast Absent 3C

Specimen 3D: postnatal adult (more )
Note: on the 11th day of gestation
Structure Level Pattern Image Note
TS28: decidua Present 3D
TS28: endometrium epithelium Present 3D
TS28: endometrium stroma Absent 3D

Specimen 3E: postnatal adult (more )
Structure Level Pattern Image Note
TS28: oocyte Present Diffuse 3E
TS28: ovary follicle cell Present Diffuse 3E
TS28: mesenchymal stroma of ovary Absent 3E

Specimen 3F: postnatal adult (more )
Structure Level Pattern Image Note
TS28: Leydig cell Moderate 3F
TS28: Sertoli cell Moderate 3F
TS28: spermatogonium Moderate 3F
TS28: spermatid Absent 3F
TS28: spermatocyte Absent 3F

Specimen 4A: embryonic day 11.0 (more )
Structure Level Pattern Image Note
TS19: dorsal root ganglion Present 4A
TS19: surface ectoderm Present 4A
TS19: urogenital ridge Present 4A
TS19: heart Present 4A somewhat weaker signal
TS19: liver Present 4A somewhat weaker signal
TS19: lung Present 4A somewhat weaker signal

Specimen 4B: embryonic day 11.0 (more )
Structure Level Pattern Image Note
TS19: mesonephric tubule Strong 4B
TS19: nephric duct Strong 4B
TS19: gonad Present 4B

Specimen 4C: embryonic day 11.0 (more )
Structure Level Pattern Image Note
TS19: dorsal root ganglion Strong 4C

Specimen 4D: embryonic day 11.0 (more )
Structure Level Pattern Image Note
TS19: liver parenchyma Moderate 4D

Specimen 4E: embryonic day 11.0 (more )
Structure Level Pattern Image Note
TS19: lobar bronchus epithelium Strong 4E
TS19: pleura Strong 4E
TS19: lung mesenchyme Present 4E a weaker signal

Specimen 4F: embryonic day 11.0 (more )
Structure Level Pattern Image Note
TS19: endocardial lining Present 4F
TS19: pericardium Present 4F
TS19: heart blood vessel Present Regionally restricted 4F Expressed in the capillaries.
TS19: cardiac muscle tissue Absent 4F

Specimen 5A: embryonic day 17.0 (more )
Structure Level Pattern Image Note
TS25: mesenchyme of metanephros Present Regionally restricted 5A Expressed in the pretubular aggregating mesenchyme cells around the tips of the branching collecting duct. Expression in the undifferentiated metanephric mesenchyme cells was barely detectable.
TS25: pretubular aggregate Present 5A
TS25: ureteric tip Present 5A
TS25: collecting duct Strong 5A

Specimen 5B: postnatal adult (more )
Structure Level Pattern Image Note
TS28: collecting duct Strong 5B
TS28: glomerular tuft Strong 5B
TS28: renal distal tubule Strong 5B
TS28: renal proximal tubule Weak 5B weak or negligible labelling

Specimen 5C: embryonic day 17.0 (more )
Structure Level Pattern Image Note
TS25: intestine epithelium Present Regionally restricted 5C Expressed in the differentiating intestinal epithelium located in the crypts.
TS25: intestinal villus Strong Regionally restricted 5C Expressed in the basal and middle regions of the villi. The signal in the tips of the villi was clearly weaker.
TS25: small intestine mucosa Strong Regionally restricted 5C Expressed in the basal and middle regions of the villi. The signal in the tips of the villi was clearly weaker.

Specimen 5E: postnatal adult (more )
Structure Level Pattern Image Note
TS28: bile duct epithelium Present 5E
TS28: hepatic vein Present Regionally restricted 5E Expressed in the endothelial cells.
TS28: liver vasculature Present Regionally restricted 5E Expressed in capillaries.
TS28: liver parenchyma Absent 5E

Specimen 5F: embryonic day 17.0 (more )
Structure Level Pattern Image Note
TS25: stomach epithelium Present Uniform 5F a rather uniform, diffuse signal

Specimen 5G: postnatal adult (more )
Structure Level Pattern Image Note
TS28: stomach epithelium Present Regionally restricted 5G Expressed in the parietal cells as a weaker signal compared with that of chief cells and mucous neck cells.
TS28: stomach mucosa Strong Regionally restricted 5G Expressed in the mucous neck cells and chief cells.

Specimen 5H: embryonic day 17.0 (more )
Structure Level Pattern Image Note
TS25: lobar bronchus epithelium Strong 5H distinct apical accumulation
TS25: alveolus epithelium Absent 5H Expression declined abruptly.
TS25: lung vascular element Present 5H

Specimen 5I: embryonic day 11.0 (more )
Structure Level Pattern Image Note
TS18: inner ear Strong Regionally restricted 5I Expression was prominent in the endolymphatic duct whereas the semicircular canals showed weak expression.

Specimen 6A: embryonic day 17.0 (more )
Structure Level Pattern Image Note
TS25: tooth epithelium Strong Regionally restricted 6A Expressed in the epithelial ameloblasts.
TS25: stratum intermedium Strong 6A
TS25: tooth mesenchyme Strong Regionally restricted 6A Expressed strongly in the mesenchymal odontoblasts. The dental mesenchyme, giving rise to odontoblasts, showed a weaker labeling.
TS25: dental papilla Absent 6A

Specimen 6B: embryonic day 17.0 (more )
Structure Level Pattern Image Note
TS25: 4th ventricle choroid plexus epithelium Strong 6B
TS25: brain blood vessel Present 6B
TS25: 4th ventricle ependyma Absent 6B

Specimen 6C: embryonic day 17.0 (more )
Structure Level Pattern Image Note
TS25: dorsal root ganglion Present 6C Expressed in the ganglion cells. Weaker or negligible labeling in the nerve fibers and satellite cells.

Specimen 6D: embryonic day 13.0 (more )
Structure Level Pattern Image Note
TS21: rib cartilage condensation Present Regionally restricted 6D Expressed in the chondroblasts.

Specimen 6E: embryonic day 15.0 (more )
Structure Level Pattern Image Note
TS23: rib cartilage Strong Regionally restricted 6E Expressed strongly in the rim of osteoblasts. Also expressed in the chondroblasts.

Specimen 6F: postnatal adult (more )
Structure Level Pattern Image Note
TS28: rib cartilage Present Regionally restricted 6F Expressed in the osteocytes whereas the periosteal cells were negative.

Specimen not shown: embryonic day 8.0 (more )
Structure Level Pattern Image Note
TS12: embryo ectoderm Weak
TS12: embryo endoderm Weak
TS12: embryo mesoderm Weak
TS12: allantois Present

Specimen not shown: postnatal adult (more )
Note: Day 8 of pregnancy.
Structure Level Pattern Image Note
TS28: decidua Present

Specimen not shown: embryonic day 11.0 (more )
Structure Level Pattern Image Note
TS18: cartilage condensation Present
TS18: dorsal root ganglion Present
TS18: liver parenchyma Present
TS18: mesonephric tubule Present
TS18: nephric duct Present
TS18: ureteric bud Present
TS18: metanephric mesenchyme Weak Expressed in undifferentiated mesenchyme.
TS18: lung epithelium Present Regionally restricted Expressed in bronchial epithelium.
TS18: lung Weak Regionally restricted Expressed in parenchymal cells.

Specimen not shown: embryonic day 15.0 (more )
Structure Level Pattern Image Note
TS23: mesenchyme of metanephros Present Regionally restricted Expressed in aggregating mesenchyme.
TS23: bile duct epithelium Present
TS23: choroid plexus Present
TS23: collecting duct Present
TS23: dorsal root ganglion Present
TS23: early distal tubule Present
TS23: maturing glomerular tuft Present
TS23: early proximal tubule Present Regionally restricted Expressed in proximal tubules in cortex, not in medulla.
TS23: metanephros epithelium Present Regionally restricted Expressed in urothelium.
TS23: liver parenchyma Weak
TS23: lung epithelium Present Regionally restricted Expressed in the bronchial epithelium, not alveolar epithelium.
TS23: lung parenchyma Present Somewhat weaker expression in the parencymal cells.

Specimen not shown: embryonic day 17.0 (more )
Structure Level Pattern Image Note
TS25: bile duct epithelium Present
TS25: choroid plexus Present
TS25: conjunctival sac Present
TS25: endolymphatic duct Present
TS25: glomerular tuft Present
TS25: lens epithelium Present
TS25: pelvic urothelial lining Present
TS25: renal distal tubule Present
TS25: urothelium of ureter Present
TS25: metanephros epithelium Present Regionally restricted Expressed in urothelium.
TS25: liver parenchyma Weak
TS25: bone Present Regionally restricted Expressed in the osteoblasts and osteocytes.
TS25: rib cartilage Present Regionally restricted Expressed in chondroblasts.
TS25: thymus Present Regionally restricted Expressed in lymphocytes and epithelium.
TS25: brain blood vessel Present Regionally restricted Expressed in endothelial cells.
TS25: brain ependyma Absent
TS25: cornea Absent
TS25: nerve Absent
TS25: sclera Absent

Specimen not shown: postnatal adult (more )
Structure Level Pattern Image Note
TS28: adrenal cortex Present
TS28: blood vessel endothelium Present
TS28: esophagus squamous epithelium Present
TS28: hair follicle Present
TS28: large intestine epithelium Present
TS28: pancreatic duct Present
TS28: pelvic urothelial lining Present
TS28: urothelium of ureter Present
TS28: adrenal medulla Absent
TS28: cardiac muscle tissue Absent
TS28: dermis Absent
TS28: skeletal muscle Absent
TS28: smooth muscle tissue Absent
TS28: oral epithelium Present Expressed in squamous epithelium.
TS28: stomach mucosa Present Expressed in the chief cells.
TS28: small intestine epithelium Present Regionally restricted Expressed in crypt epithelium, not in the tips of villi.
TS28: exocrine pancreas Present Regionally restricted Expressed in most acinar cells.
TS28: salivary gland Present Regionally restricted Expressed in mucous and serous acini.
TS28: thyroid gland follicle Present Regionally restricted Expressed in the epithelium.
TS28: alveolus epithelium Absent
TS28: bone Present Regionally restricted Expressed in osteocytes.
TS28: cartilage Present Regionally restricted Expressed in the chondrocytes.
TS28: lymph node Present Expressed in the lymphocytes.
TS28: spleen Present Expressed in the lymphocytes.
TS28: spleen vascular element Present Regionally restricted Expressed in the endothelial cells.
TS28: small intestine mucosa Strong Regionally restricted Expressed in the crypts and in the basal and middle region of the villi. The signal was less pronounced in the mature cells close to the tips of the villi.


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/19/2021
MGI 6.17
The Jackson Laboratory