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Gene Expression Data
Assay Details
Assay
Reference: J:242313 Forge A, et al., Disruption of SorCS2 reveals differences in the regulation of stereociliary bundle formation between hair cell types in the inner ear. PLoS Genet. 2017 Mar;13(3):e1006692
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6414808
Gene symbol: Sorcs2
Gene name: sortilin-related VPS10 domain containing receptor 2
Antibody: anti-Sorcs2 (R&D; AF4237)
Detection system: Secondary antibody coupled to Alexa Fluor
Results
Specimen 2A: embryonic day 15.0-15.5 (more )
Note: Double labeled: green - Sorcs2; red - actin
Structure Level Pattern Image Note
TS23: cochlea Absent 2A No expression is seen in the cochlear basal turn.

Specimen 2B: embryonic day 18.0 (more )
Note: Double labeled: green - Sorcs2; red - actin
Structure Level Pattern Image Note
TS26: cochlea Present Regionally restricted 2B Expression is localized to inner and outer hair cells in the basal turn.

Specimen 2C: embryonic day 18.0 (more )
Note: Double labeled: green - Sorcs2; red - actin
Structure Level Pattern Image Note
TS26: cochlea Present Regionally restricted 2C Expression is localized to inner hair cells in the apical turn.

Specimen 2D: embryonic day 18.0 (more )
Note: Double labeled: green - Sorcs2; red - actin
Structure Level Pattern Image Note
TS26: macula of utricle Present Regionally restricted 2D Expression is localized to presumptive immature hair cells lacking stereociliary bundles and in hair cells with bundles.

Specimen 2E: embryonic day 18.0 (more )
Note: Double labeled: green - Sorcs2; red - actin
Structure Level Pattern Image Note
TS26: macula of utricle Present Regionally restricted 2E Expression is localized to presumptive immature hair cells lacking stereociliary bundles and in hair cells with bundles.

Specimen 2F: embryonic day 18.0 (more )
Note: Double labeled: green - Sorcs2; red - actin
Structure Level Pattern Image Note
TS26: crista ampullaris Present Regionally restricted 2F Expression is localized to presumptive immature hair cells lacking stereociliary bundles and in hair cells with bundles.

Specimen 2G: postnatal day 0 (more )
Note: Double labeled: green - Sorcs2; red - actin. Littermates were used for this study; this animal may be heterozygous for the Tie-cre transgene.
Structure Level Pattern Image Note
TS27: organ of Corti Present Regionally restricted 2G Expression is localised to hair cells and supporting cells.

Specimen 2H: postnatal day 0; Tg(Tek-cre)1Ywa/Tg(Tek-cre)1Ywa (more )
Note: Double labeled: green - Sorcs2; red - actin
Structure Level Pattern Image Note
TS27: organ of Corti Absent 2H No expression is seen in hair cells and supporting cells.

Specimen S2C: postnatal day 1 (more )
Note: DAPI stained (red). Littermates were used for this study; this animal may be heterozygous for the Tie-cre transgene.
Structure Level Pattern Image Note
TS27: cochlea Present Regionally restricted S2C' , S2C Expression is localized to hair cells and supporting cells in the basal turn.

Specimen S2D: postnatal day 1 (more )
Note: DAPI stained (red). Littermates were used for this study; this animal may be heterozygous for the Tie-cre transgene.
Structure Level Pattern Image Note
TS27: cochlea Present Regionally restricted S2D , S2D' Expression is localized to hair cells and supporting cells in the apical turn.

Specimen S2E: postnatal day 1; Tg(Tek-cre)1Ywa/Tg(Tek-cre)1Ywa (more )
Note: DAPI stained (red).
Structure Level Pattern Image Note
TS27: cochlea Absent S2E , S2E' No expression was detected in the basal turn.

Specimen S2F: postnatal day 1; Tg(Tek-cre)1Ywa/Tg(Tek-cre)1Ywa (more )
Note: DAPI stained (red).
Structure Level Pattern Image Note
TS27: cochlea Absent S2F , S2F' No expression was detected in the apical turn.

Specimen S2G: postnatal day 30 (more )
Note: DAPI stained (blue).
Structure Level Pattern Image Note
TS28: cochlea Present Regionally restricted S2G Expression is primarily seen in supporting cells.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/04/2020
MGI 6.15
The Jackson Laboratory