About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:233609 Van Otterloo E, et al., MEMO1 drives cranial endochondral ossification and palatogenesis. Dev Biol. 2016 Jul 15;415(2):278-95
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:6400513
Gene symbol: Memo1
Gene name: mediator of cell motility 1
Reporter: lacZ
Direct Detection
Results
Specimen 4D: embryonic day 13.5; Memo1tm1a(EUCOMM)Wtsi/Memo1+ (more )
Note: Single palatal shelf prior to palatal fusion.
Structure Level Pattern Image Note
TS21: palatal shelf mesenchyme Present Diffuse 4D Diffuse expression throughout nasal side of palatal shelf mesenchyme.

Specimen 4E: embryonic day 15.5; Memo1tm1a(EUCOMM)Wtsi/Memo1+ (more )
Note: Subsequent to secondary palatal fusion. Frontal section slightly more posterior than section shown in 4F.
Structure Level Pattern Image Note
TS23: palatal shelf Present Regionally restricted 4E Expression reduced at midline of palate; enriched expression at periphery near developing maxillary bones.
TS23: maxilla Present 4E Expression within maxillary bones.
TS23: nasal septum cartilage Present Regionally restricted 4E Expression in presumptive perichondrium surrounding nasal cartilage.
TS23: nasal septum epithelium Weak 4E Far less prominent expression in ectoderm of palatal shelves or nasal septum.
TS23: palatal shelf epithelium Weak 4E Far less prominent expression in ectoderm of palatal shelves or nasal septum.

Specimen 4F: embryonic day 15.5; Memo1tm1a(EUCOMM)Wtsi/Memo1+ (more )
Note: Subsequent to secondary palatal fusion
Structure Level Pattern Image Note
TS23: palatal shelf Present Regionally restricted 4F Expression reduced at midline of palate; enriched expression at periphery near developing maxillary bones.
TS23: nasal septum epithelium Weak 4F Far less prominent expression in ectoderm of palatal shelves or nasal septum.
TS23: palatal shelf epithelium Weak 4F Far less prominent expression in ectoderm of palatal shelves or nasal septum.

Specimen 4G: embryonic day 15.5; Memo1tm1a(EUCOMM)Wtsi/Memo1+ (more )
Note: Mid-sagittal section of entire head.
Structure Level Pattern Image Note
TS23: basioccipital bone Strong Regionally restricted 4G Strong expression in perichondrium and periosteum.
TS23: basisphenoid bone Strong Regionally restricted 4G Strong expression in perichondrium and periosteum.
TS23: nasal septum cartilage Strong Regionally restricted 4G Strong expression in perichondrium and periosteum.
TS23: secondary palate Strong Regionally restricted 4G Strong expression in perichondrium and periosteum.
TS23: choroid plexus Present 4G
TS23: pituitary gland Present 4G
TS23: tongue Present 4G

Specimen 4H: embryonic day 15.5; Memo1tm1a(EUCOMM)Wtsi/Memo1+ (more )
Note: Secondary palate and anterior cranial base.
Structure Level Pattern Image Note
TS23: maxilla Strong Regionally restricted 4H Strong expression in perichondrium and periosteum.
TS23: viscerocranium bone Strong Regionally restricted 4H Strong expression in perichondrium and periosteum.
TS23: tongue Present 4H

Specimen 4I: embryonic day 15.5; Memo1tm1a(EUCOMM)Wtsi/Memo1+ (more )
Note: Mid-cranial base.
Structure Level Pattern Image Note
TS23: basisphenoid bone Strong Regionally restricted 4I Strong expression in perichondrium. Lower levels of expression in cells at various stages of chondrocyte differentiation.
TS23: cranium Present Regionally restricted 4I Expression within developing cranial base bones.
TS23: pituitary gland Present 4I

Specimen 4J: embryonic day 15.5; Memo1tm1a(EUCOMM)Wtsi/Memo1+ (more )
Note: Posterior cranial base.
Structure Level Pattern Image Note
TS23: basioccipital bone Strong Regionally restricted 4J Strong expression in periosteum.
TS23: cranium Present Regionally restricted 4J Expression within developing cranial base bones.

Specimen 4K: embryonic day 15.5; Memo1tm1a(EUCOMM)Wtsi/Memo1+ (more )
Note: Snout.
Structure Level Pattern Image Note
TS23: vibrissa Present 4K


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/22/2022
MGI 6.21
The Jackson Laboratory