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Gene Expression Data
Assay Details
Assay
Reference: J:211921 McKeown CR, et al., Tropomyosin is required for cardiac morphogenesis, myofibril assembly, and formation of adherens junctions in the developing mouse embryo. Dev Dyn. 2014 Jun;243(6):800-17
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6192667
Gene symbol: Actn2
Gene name: actinin alpha 2
Results
Specimen 5B/C: embryonic day 8.5 (more )
Note: Double labeled: green - Actn2; red - F-actin.
Structure Level Pattern Image Note
TS13: cardiac muscle tissue Present Regionally restricted 5B/C Expression in cardiomyocytes in outer wall of heart, organized in typical striated myofibrils with periodic Z-lines gaps in H-zones.

Specimen 5E/F: embryonic day 8.5; Tpm1tm1Dfw/Tpm1tm1Dfw (more )
Note: Double labeled: green - Actn2; red - F-actin.
Structure Level Pattern Image Note
TS13: cardiac muscle tissue Present Regionally restricted 5E/F Expression in cardiomyocytes in outer wall of heart, organized in irregular puncta along F-actin fibrils.

Specimen 5H/I: embryonic day 8.5 (more )
Note: Double labeled: green - Actn2; red - F-actin.
Structure Level Pattern Image Note
TS13: cardiac muscle tissue Present Regionally restricted 5H/I Expression organized in striated myofibrils with periodic Z-lines gaps in H-zones.

Specimen 5K/L: embryonic day 8.5; Tpm1tm1Dfw/Tpm1tm1Dfw (more )
Note: Double labeled: green - Actn2; red - F-actin.
Structure Level Pattern Image Note
TS13: cardiac muscle tissue Present Regionally restricted 5K/L Expression in aberrant puncta (Z-bodies).

Specimen 10A/C: embryonic day 8.5 (more )
Note: Double labeled: green - Actn2; red - F-actin.
Structure Level Pattern Image Note
TS13: cardiac muscle tissue Present Regionally restricted 10A , 10C Expression in cardiomycytes in continuous circumferential belts near apical ends of cells along outer surface of heart.

Specimen 10D/F: embryonic day 8.5; Tpm1tm1Dfw/Tpm1tm1Dfw (more )
Note: Double labeled: green - Actn2; red - F-actin.
Structure Level Pattern Image Note
TS13: cardiac muscle tissue Present Regionally restricted 10D , 10F Expression in cardiomyocytes assembled into puncta and occasional rods associated with disorganized F-actin fibrils in the cytoplasm.

Specimen 10G/I: embryonic day 8.5; Tmod1tm1Vmf/Tmod1tm1Vmf (more )
Note: Double labeled: green - Actn2; red - F-actin.
Structure Level Pattern Image Note
TS13: cardiac muscle tissue Present Regionally restricted 10G , 10I Expression in cardiomyocytes predominantly assembles into rods staining weakly for F-actin.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/04/2020
MGI 6.15
The Jackson Laboratory