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Gene Expression Data
Assay Details
Assay
Reference: J:74098 Hermey G, et al., Transient expression of SorCS in developing telencephalic and mesencephalic structures of the mouse. Neuroreport. 2001 Jan 22;12(1):29-32
Assay type: RNA in situ
MGI Accession ID: MGI:5285109
Gene symbol: Sorcs1
Gene name: sortilin-related VPS10 domain containing receptor 1
Probe: SorCS cDNA1
Probe preparation: Antisense RNA labelled with S35
Visualized with: Autoradiography
Results
Specimen 1a E12.5: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: central nervous system Present 1a E12.5
TS20: midbrain roof plate Strong 1a E12.5
TS20: telencephalon Strong 1a E12.5
TS20: 3rd ventricle Strong Regionally restricted 1a E12.5 Expression is at the base.
TS20: midbrain Strong Regionally restricted 1a E12.5 Expression is in the midbrain-forebrain boundary.

Specimen 1a E14.5: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: main olfactory bulb Present 1a E14.5
TS22: cerebral cortex Present Regionally restricted 1a E14.5 Expression is in the dorsomedial region.
TS22: inferior colliculus Present 1a E14.5
TS22: superior colliculus Present 1a E14.5
TS22: midbrain tegmentum Present Regionally restricted 1a E14.5 Expression is ventral.

Specimen 1a E16.5: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: cerebral cortex Present 1a E16.5
TS24: cortical plate Present 1a E16.5

Specimen 1d: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: midbrain Strong Regionally restricted 1d Expression is in the midbrain-forebrain boundary.

Specimen 1e: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: inferior colliculus Present 1e
TS22: main olfactory bulb Present 1e
TS22: superior colliculus Present 1e
TS22: cerebral cortex Present Regionally restricted 1e Expression is in the dorsomedial region.
TS22: midbrain tegmentum Present Regionally restricted 1e Expression is ventral.
TS22: midbrain Strong Regionally restricted 1e Expression is in dopaminergic nuclei.

Specimen 1f: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: superior colliculus Strong 1f
TS24: inferior colliculus Present 1f
TS24: cerebellum Strong Regionally restricted 1f Expression is in deep cerebellar nuclei and in the external granular cell layer.
TS24: midbrain Strong Regionally restricted 1f Expression is in dopaminergic nuclei.

Specimen 1g: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: medulla oblongata Present Regionally restricted 1g Expression is in the medial vestibular nucleus.

Specimen 2a: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: cerebral cortex Present 2a
TS27: cortical layer V Very strong 2a
TS27: globus pallidus Very strong 2a

Specimen 2b: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: cerebral cortex Present 2b
TS27: cortical layer V Very strong 2b

Specimen 2c: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: cerebral cortex Present 2c

Specimen 2d: postnatal day 3 (more )
Structure Level Pattern Image Note
TS27: cerebral cortex Present 2d
TS27: globus pallidus Present 2d
TS27: cortical layer V Very strong 2d

Specimen 2e: postnatal day 3 (more )
Structure Level Pattern Image Note
TS27: cerebral cortex Present 2e
TS27: deep cerebellar nucleus Present 2e
TS27: pontine nucleus Present 2e
TS27: cortical layer V Very strong 2e
TS27: midbrain Present Regionally restricted 2e Expression is in dopaminergic nuclei.

Specimen 2f: postnatal day 3 (more )
Structure Level Pattern Image Note
TS27: cerebral cortex Present 2f
TS27: deep cerebellar nucleus Present 2f
TS27: pontine nucleus Present 2f
TS27: cortical layer V Very strong 2f
TS27: midbrain Very strong Regionally restricted 2f Expression is in dopaminergic nuclei.

Specimen 3a,a': embryonic day 14.5 (more )
Note: Brightfield/darkfield pair.
Structure Level Pattern Image Note
TS22: neural retinal epithelium Present Regionally restricted 3a , 3a' Expression is at the outer tip of the neural retina that borders the iris.
TS22: optic nerve Present Regionally restricted 3a' , 3a Expression is at the retina-optic nerve transition.
TS22: retina Present Regionally restricted 3a' , 3a Expression is at the retina-optic nerve transition.

Specimen 3b,b': embryonic day 16.5 (more )
Note: Brightfield/darkfield pair.
Structure Level Pattern Image Note
TS24: neural retina Weak 3b' , 3b
TS24: optic nerve Present Regionally restricted 3b , 3b' Expression is at the retina-optic nerve transition and in the optic nerve.

Specimen 3c,c': postnatal day 0 (more )
Note: Brightfield/darkfield pair.
Structure Level Pattern Image Note
TS27: optic nerve Present 3c' , 3c
TS27: retina Weak 3c , 3c'

Specimen 3d,d': postnatal day 3 (more )
Note: Brightfield/darkfield pair.
Structure Level Pattern Image Note
TS27: optic nerve Present 3d , 3d'
TS27: retina Weak 3d , 3d'

Specimen 3e,e: postnatal day 3 (more )
Note: Brightfield/darkfield pair.
Structure Level Pattern Image Note
TS27: optic nerve Present 3e' , 3e
TS27: retina Weak 3e , 3e'

Specimen Not shown, adult: postnatal adult (more )
Structure Level Pattern Image Note
TS28: retina layer Weak Regionally restricted Expression is in the inner granular layer.
TS28: retina ganglion cell layer Weak
TS28: optic nerve Absent Expression was absent after P3.

Specimen 4a,a': embryonic day 14.5 (more )
Note: Brightfield/darkfield pair.
Structure Level Pattern Image Note
TS22: dorsal root ganglion Present 4a' , 4a

Specimen 4b,b': embryonic day 16.5 (more )
Note: Brightfield/darkfield pair.
Structure Level Pattern Image Note
TS24: neurohypophysis Present 4b , 4b'
TS24: adenohypophysis Absent 4b' , 4b

Specimen 4c,c': postnatal adult (more )
Note: Brightfield/darkfield pair.
Structure Level Pattern Image Note
TS28: adenohypophysis Present 4c' , 4c
TS28: neurohypophysis Absent 4c' , 4c


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory