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Gene Expression Data
Assay Details
Assay
Reference: J:157819 Shimogori T, et al., A genomic atlas of mouse hypothalamic development. Nat Neurosci. 2010;13(6):767-75
Assay type: RNA in situ
MGI Accession ID: MGI:4450868
Gene symbol: Nrg1
Gene name: neuregulin 1
Probe: UI-M-BH1-ako-d-12-0-UI.s1
Probe preparation: Antisense RNA labelled with digoxigenin
Visualized with: Alkaline phosphatase
Results
Specimen S8f: embryonic day 11.5 (more )
Note: This specimen was double labeled; see also MGI:4452154.
Structure Level Pattern Image Note
TS19: diencephalon Present Regionally restricted S8_f Expression is present in a domain in the dorsomedial prethalamus and dorsal hypothalamus.

Specimen S8g: embryonic day 11.5 (more )
Note: This specimen was double labeled; see also MGI:4452154.
Structure Level Pattern Image Note
TS19: diencephalon Present Regionally restricted S8_g Expression is present in a domain in the dorsomedial prethalamus and dorsal hypothalamus.

Specimen S8h: embryonic day 11.5 (more )
Note: This specimen was double labeled; see also MGI:4452154.
Structure Level Pattern Image Note
TS19: diencephalon Present Regionally restricted S8_h Expression is present in a domain in the dorsomedial prethalamus and dorsal hypothalamus.

Specimen S8i: embryonic day 11.5 (more )
Note: This specimen was double labeled; see also MGI:4452154.
Structure Level Pattern Image Note
TS19: diencephalon Present Regionally restricted S8_i Expression is present in a domain in the dorsomedial prethalamus and dorsal hypothalamus.

Specimen Nrg1 - E11.5: embryonic day 11.5 (more )
Note: Specimen was also hybridized with a fluorescein-labeled Shh probe (MGI:2110655; detected with TBT/BCIP). The results are reported in Supp. Table 4, whose legend includes a key to the abbreviations used and more fully details the regions examined.
Structure Level Pattern Image Note
TS19: diencephalon lateral wall mantle layer Moderate Non-Uniform Nrg1-Shh E11.5 sagittal , Nrg1-Shh E11.5 coronal Staining is moderate in the MZ of the prethalamus & weak in the mam zone. Staining is either absent or ubiquitous in the MZ of the dorsal thalamus, dorsal & ventral POAs, PVH, VMH & ARH nuclei, AVH, anterior & posterior IDs, premam & supramam zones & TT.
TS19: diencephalon lateral wall ventricular layer Ambiguous Nrg1-Shh E11.5 sagittal , Nrg1-Shh E11.5 coronal Staining is either absent or ubiquitous in the ventricular zone of the dorsal thalamus, the prethalamus, dorsal and ventral POAs, the PVH, VMH and ARH nuclei, the AVH, the anterior and posterior IDs, the premam, mam and supramam zones and the TT.
TS19: telencephalon mantle layer Weak Nrg1-Shh E11.5 sagittal , Nrg1-Shh E11.5 coronal There is weak staining in the postmitotic neurons in the intermediate zone and cortical plate of the cerebral cortex and in the mantle zone of the ganglionic eminences.
TS19: telencephalon ventricular layer Ambiguous Nrg1-Shh E11.5 coronal , Nrg1-Shh E11.5 sagittal Staining is either absent or ubiquitous in the ventricular zone of the cerebral cortex and the ganglionic eminences.

Specimen Nrg1 - E12.5: embryonic day 12.5 (more )
Note: Specimen was also hybridized with a fluorescein-labeled Shh probe (MGI:2110655; detected with TBT/BCIP). The results are reported in Supp. Table 4, whose legend includes a key to the abbreviations used and more fully details the regions examined.
Structure Level Pattern Image Note
TS20: cerebral cortex intermediate zone Ambiguous Nrg1-Shh E12.5 sagittal , Nrg1-Shh E12.5 coronal Staining is either absent or ubiquitous in the postmitotic neurons in the intermediate zone of the cerebral cortex.
TS20: cerebral cortex ventricular layer Moderate Nrg1-Shh E12.5 sagittal , Nrg1-Shh E12.5 coronal There is moderate staining in the ventricular zone of the cerebral cortex.
TS20: cortical plate Ambiguous Nrg1-Shh E12.5 sagittal , Nrg1-Shh E12.5 coronal Staining is either absent or ubiquitous in the postmitotic neurons in the cortical plate of the cerebral cortex.
TS20: diencephalon mantle layer Weak Non-Uniform Nrg1-Shh E12.5 sagittal , Nrg1-Shh E12.5 coronal There is weak staining in the mantle zone of the mam zone. Staining is either absent or ubiquitous in the mantle zone of the premam and supramam zones and the TT.
TS20: diencephalon ventricular layer Ambiguous Nrg1-Shh E12.5 coronal , Nrg1-Shh E12.5 sagittal Staining is either absent or ubiquitous in the ventricular zone of the premam, mam and supramam zones and the TT.
TS20: ganglionic eminence Moderate Non-Uniform Nrg1-Shh E12.5 coronal , Nrg1-Shh E12.5 sagittal There is moderate staining in the ventricular zone of the ganglionic eminences. Staining is either absent or ubiquitous in the mantle zone of the ganglionic eminences.
TS20: hypothalamus mantle layer Moderate Non-Uniform Nrg1-Shh E12.5 coronal , Nrg1-Shh E12.5 sagittal There is moderate staining in the mantle zone of the PVH nucleus. Staining is either absent or ubiquitous in the mantle zone of the dorsal and ventral POAs, the VMH and ARH nuclei, the AVH and anterior and posterior IDs.
TS20: hypothalamus ventricular layer Ambiguous Nrg1-Shh E12.5 coronal , Nrg1-Shh E12.5 sagittal Staining is either absent or ubiquitous in the ventricular zone of the dorsal and ventral POAs, the PVH, VMH and ARH nuclei, the AVH and anterior and posterior IDs.
TS20: thalamus mantle layer Moderate Non-Uniform Nrg1-Shh E12.5 coronal , Nrg1-Shh E12.5 sagittal There is moderate staining in the mantle zone of the prethalamus. Staining is either absent or ubiquitous in the mantle zone of the dorsal thalamus.
TS20: thalamus ventricular layer Ambiguous Nrg1-Shh E12.5 coronal , Nrg1-Shh E12.5 sagittal Staining is either absent or ubiquitous in the ventricular zone of the dorsal thalamus and prethalamus.

Specimen Nrg1 - E14.5: embryonic day 14.5 (more )
Note: Specimen was also hybridized with a fluorescein-labeled Shh probe (MGI:2110655; detected with TBT/BCIP). The results are reported in Supp. Table 4, whose legend includes a key to the abbreviations used and more fully details the regions examined.
Structure Level Pattern Image Note
TS22: cerebral cortex intermediate zone Ambiguous Nrg1-Shh E14.5 sagittal , Nrg1-Shh E14.5 coronal Staining is either absent or ubiquitous in the postmitotic neurons in the intermediate zone of the cerebral cortex.
TS22: cerebral cortex ventricular layer Strong Nrg1-Shh E14.5 coronal , Nrg1-Shh E14.5 sagittal There is strong staining in the ventricular zone of the cerebral cortex.
TS22: cortical plate Ambiguous Nrg1-Shh E14.5 coronal , Nrg1-Shh E14.5 sagittal Staining is either absent or ubiquitous in the postmitotic neurons in the cortical plate of the cerebral cortex.
TS22: diencephalon mantle layer Ambiguous Nrg1-Shh E14.5 sagittal , Nrg1-Shh E14.5 coronal Staining is either absent or ubiquitous in the mantle zone of the premam, mam and supramam zones and the TT.
TS22: diencephalon ventricular layer Weak Non-Uniform Nrg1-Shh E14.5 sagittal , Nrg1-Shh E14.5 coronal There is weak staining in the ventricular zone of the mam zone. Staining is either absent or ubiquitous in the ventricular zone of the premam and supramam zones and the TT.
TS22: ganglionic eminence Strong Non-Uniform Nrg1-Shh E14.5 sagittal , Nrg1-Shh E14.5 coronal There is strong staining in the ventricular zone of the ganglionic eminences. Staining is either absent or ubiquitous in the mantle zone of the ganglionic eminences.
TS22: hypothalamus mantle layer Moderate Non-Uniform Nrg1-Shh E14.5 coronal , Nrg1-Shh E14.5 sagittal There is moderate staining in the mantle zone of the PVH nucleus. Staining is either absent or ubiquitous in the mantle zone of the dorsal and ventral POAs, the VMH and ARH nuclei, the AVH and anterior and posterior IDs.
TS22: hypothalamus ventricular layer Ambiguous Nrg1-Shh E14.5 coronal , Nrg1-Shh E14.5 sagittal Staining is either absent or ubiquitous in the ventricular zone of the dorsal and ventral POAs, the PVH, VMH and ARH nuclei, the AVH and anterior and posterior IDs.
TS22: thalamus mantle layer Moderate Non-Uniform Nrg1-Shh E14.5 sagittal , Nrg1-Shh E14.5 coronal There is moderate staining in the mantle zone of the dorsal thalamus and weak staining in the prethalamus.
TS22: thalamus ventricular layer Ambiguous Nrg1-Shh E14.5 coronal , Nrg1-Shh E14.5 sagittal Staining is either absent or ubiquitous in the ventricular zone of the dorsal thalamus and prethalamus.

Specimen Nrg1 - E16.5: embryonic day 16.5 (more )
Note: Specimen was also hybridized with a fluorescein-labeled Shh probe (MGI:2110655; detected with TBT/BCIP). The results are reported in Supp. Table 4, whose legend includes a key to the abbreviations used and more fully details the regions examined.
Structure Level Pattern Image Note
TS24: cerebral cortex intermediate zone Ambiguous Nrg1-Shh E16.5 sagittal , Nrg1-Shh E16.5 coronal Staining is either absent or ubiquitous in the postmitotic neurons in the intermediate zone of the cerebral cortex.
TS24: cerebral cortex ventricular layer Very strong Nrg1-Shh E16.5 coronal , Nrg1-Shh E16.5 sagittal There is very strong staining in the ventricular zone of the cerebral cortex.
TS24: cortical plate Ambiguous Nrg1-Shh E16.5 sagittal , Nrg1-Shh E16.5 coronal Staining is either absent or ubiquitous in the postmitotic neurons in the cortical plate of the cerebral cortex.
TS24: diencephalon mantle layer Weak Non-Uniform Nrg1-Shh E16.5 coronal , Nrg1-Shh E16.5 sagittal There is weak staining in the mantle zone of the mam zone. Staining is either absent or ubiquitous in the mantle zone of the premam and supramam zones.
TS24: diencephalon ventricular layer Ambiguous Nrg1-Shh E16.5 sagittal , Nrg1-Shh E16.5 coronal Staining is either absent or ubiquitous in the ventricular zone of the premam, mam and supramam zones.
TS24: ganglionic eminence Ambiguous Nrg1-Shh E16.5 sagittal , Nrg1-Shh E16.5 coronal Staining is either absent or ubiquitous in the ventricular and mantle zones of the ganglionic eminences.
TS24: hypothalamus mantle layer Moderate Non-Uniform Nrg1-Shh E16.5 coronal , Nrg1-Shh E16.5 sagittal There is moderate staining in the mantle zone of the PVH nucleus. Staining is either absent or ubiquitous in the mantle zone of the dorsal and ventral POAs, the SCH, DMH, VMH and ARH nuclei, the AVH, the DAH and the PH.
TS24: hypothalamus ventricular layer Ambiguous Nrg1-Shh E16.5 coronal , Nrg1-Shh E16.5 sagittal Staining is either absent or ubiquitous in the ventricular zone of the dorsal and ventral POAs, the PVH, SCH, DMH, VMH and ARH nuclei, the AVH, the DAH and the PH.
TS24: thalamus mantle layer Ambiguous Nrg1-Shh E16.5 sagittal , Nrg1-Shh E16.5 coronal Staining is either absent or ubiquitous in the mantle zone of the dorsal thalamus and prethalamus.
TS24: thalamus ventricular layer Ambiguous Nrg1-Shh E16.5 sagittal , Nrg1-Shh E16.5 coronal Staining is either absent or ubiquitous in the ventricular zone of the dorsal thalamus and prethalamus.


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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory