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Gene Expression Data
Assay Details
Assay
Reference: J:157819 Shimogori T, et al., A genomic atlas of mouse hypothalamic development. Nat Neurosci. 2010;13(6):767-75
Assay type: RNA in situ
MGI Accession ID: MGI:4450858
Gene symbol: Erbb2
Gene name: erb-b2 receptor tyrosine kinase 2
Probe: UI-M-BH3-avf-h-09-0-UI.s1
Probe preparation: Antisense RNA labelled with digoxigenin
Visualized with: Alkaline phosphatase
Assay notes: These specimens were also hybridized with a fluorescein-labeled Shh probe MGI:2110655; detected with TBT/BCIP. The results are reported in Supp. Table 4, whose legend includes a key to the abbreviations used and more fully details the regions examined.
Results
Specimen Erbb2 - E11.5: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: diencephalon lateral wall mantle layer Ambiguous Erbb2-Shh E11.5-coronal , Erbb2-Shh E11.5-sagittal Staining is either absent or ubiquitous in the mantle zone of the dorsal thalamus, the prethalamus, dorsal and ventral POAs, the PVH, VMH and ARH nuclei, the AVH, the anterior and posterior IDs, the premam, mam and supramam zones and the TT.
TS19: diencephalon lateral wall ventricular layer Moderate Non-Uniform Erbb2-Shh E11.5-sagittal , Erbb2-Shh E11.5-coronal There is moderate, scattered staining in the VZ of the dorsal thalamus, prethalamus, dorsal & ventral POAs, the PVH nucleus, the AVH & anterior ID & weak, scattered staining in the posterior ID, VMH & ARH nuclei, the premam, mam & supramam zones & the TT.
TS19: telencephalon mantle layer Ambiguous Erbb2-Shh E11.5-sagittal , Erbb2-Shh E11.5-coronal Staining is either absent or ubiquitous in the postmitotic neurons in the intermediate zone and cortical plate of the cerebral cortex and in the mantle zone of the ganglionic eminences.
TS19: telencephalon ventricular layer Moderate Scattered Erbb2-Shh E11.5-sagittal , Erbb2-Shh E11.5-coronal There is moderate, scattered staining in the ventricular zone of the cerebral cortex and the ganglionic eminences.

Specimen Erbb2 - E12.5: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: cerebral cortex intermediate zone Ambiguous Erbb2-Shh E12.5-sagittal , Erbb2-Shh E12.5-coronal Staining is either absent or ubiquitous in the postmitotic neurons in the intermediate zone of the cerebral cortex.
TS20: cerebral cortex ventricular layer Strong Scattered Erbb2-Shh E12.5-sagittal , Erbb2-Shh E12.5-coronal There is strong, scattered staining in the ventricular zone of the cerebral cortex.
TS20: cortical plate Ambiguous Erbb2-Shh E12.5-coronal , Erbb2-Shh E12.5-sagittal Staining is either absent or ubiquitous in the postmitotic neurons in the cortical plate of the cerebral cortex.
TS20: diencephalon mantle layer Ambiguous Erbb2-Shh E12.5-sagittal , Erbb2-Shh E12.5-coronal Staining is either absent or ubiquitous in the mantle zone of the premam, mam and supramam zones and the TT.
TS20: diencephalon ventricular layer Moderate Scattered Erbb2-Shh E12.5-sagittal , Erbb2-Shh E12.5-coronal There is moderate, scattered staining in the ventricular zone of the premam, mam and supramam zones and the TT.
TS20: ganglionic eminence Strong Non-Uniform Erbb2-Shh E12.5-coronal , Erbb2-Shh E12.5-sagittal There is strong, scattered staining in the ventricular zone of the ganglionic eminences. Staining is either absent or ubiquitous in the mantle zone of the ganglionic eminences.
TS20: hypothalamus mantle layer Ambiguous Erbb2-Shh E12.5-sagittal , Erbb2-Shh E12.5-coronal Staining is either absent or ubiquitous in the mantle zone of the dorsal and ventral POAs, the PVH, VMH and ARH nuclei, the AVH and anterior and posterior IDs.
TS20: hypothalamus ventricular layer Strong Non-Uniform Erbb2-Shh E12.5-sagittal , Erbb2-Shh E12.5-coronal There is strong, scattered staining in the ventricular zone of the dorsal and ventral POAs and the PVH nucleus, moderate, scattered staining in the anterior and posterior IDs and weak, scattered staining in the AVH and VMH and ARH nuclei.
TS20: thalamus mantle layer Ambiguous Erbb2-Shh E12.5-coronal , Erbb2-Shh E12.5-sagittal Staining is either absent or ubiquitous in the mantle zone of the dorsal thalamus and prethalamus.
TS20: thalamus ventricular layer Strong Scattered Erbb2-Shh E12.5-coronal , Erbb2-Shh E12.5-sagittal There is strong, scattered staining in the ventricular zone of the dorsal thalamus and prethalamus.

Specimen Erbb2 - E14.5: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: cerebral cortex intermediate zone Ambiguous Erbb2-Shh E14.5-sagittal , Erbb2-Shh E14.5-coronal Staining is either absent or ubiquitous in the postmitotic neurons in the intermediate zone of the cerebral cortex.
TS22: cerebral cortex ventricular layer Moderate Erbb2-Shh E14.5-coronal , Erbb2-Shh E14.5-sagittal There is moderate, scattered staining in the ventricular zone of the cerebral cortex.
TS22: cortical plate Ambiguous Erbb2-Shh E14.5-sagittal , Erbb2-Shh E14.5-coronal Staining is either absent or ubiquitous in the postmitotic neurons in the cortical plate of the cerebral cortex.
TS22: diencephalon mantle layer Ambiguous Erbb2-Shh E14.5-coronal , Erbb2-Shh E14.5-sagittal Staining is either absent or ubiquitous in the mantle zone of the premam, mam and supramam zones and the TT.
TS22: diencephalon ventricular layer Moderate Scattered Erbb2-Shh E14.5-coronal , Erbb2-Shh E14.5-sagittal There is moderate, scattered staining in the ventricular zone of the premam, mam and supramam zones and the TT.
TS22: ganglionic eminence Moderate Non-Uniform Erbb2-Shh E14.5-coronal , Erbb2-Shh E14.5-sagittal There is moderate, scattered staining in the ventricular zone of the ganglionic eminences. Staining is either absent or ubiquitous in the mantle zone of the ganglionic eminences.
TS22: hypothalamus mantle layer Ambiguous Erbb2-Shh E14.5-coronal , Erbb2-Shh E14.5-sagittal Staining is either absent or ubiquitous in the mantle zone of the dorsal and ventral POAs, the PVH, VMH and ARH nuclei, the AVH and anterior and posterior IDs.
TS22: hypothalamus ventricular layer Very strong Non-Uniform Erbb2-Shh E14.5-coronal , Erbb2-Shh E14.5-sagittal There is very strong staining in the ventricular zone of the dorsal and ventral POAs and the PVH nucleus, strong staining in the posterior ID, moderate, scattered staining in the anterior ID and weak, scattered staining in the AVH and VMH and ARH nuclei.
TS22: thalamus mantle layer Ambiguous Erbb2-Shh E14.5-coronal , Erbb2-Shh E14.5-sagittal Staining is either absent or ubiquitous in the mantle zone of the dorsal thalamus and prethalamus.
TS22: thalamus ventricular layer Very strong Erbb2-Shh E14.5-coronal , Erbb2-Shh E14.5-sagittal There is very strong staining in the ventricular zone of the dorsal thalamus and prethalamus.

Specimen Erbb2 - E16.5: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: cerebral cortex intermediate zone Ambiguous Erbb2-Shh E16.5-coronal , Erbb2-Shh E16.5-sagittal Staining is either absent or ubiquitous in the postmitotic neurons in the intermediate zone of the cerebral cortex.
TS24: cerebral cortex ventricular layer Very strong Erbb2-Shh E16.5-sagittal , Erbb2-Shh E16.5-coronal There is very strong staining in the ventricular zone of the cerebral cortex.
TS24: cortical plate Ambiguous Erbb2-Shh E16.5-sagittal , Erbb2-Shh E16.5-coronal Staining is either absent or ubiquitous in the postmitotic neurons in the cortical plate of the cerebral cortex.
TS24: diencephalon mantle layer Ambiguous Erbb2-Shh E16.5-sagittal , Erbb2-Shh E16.5-coronal Staining is either absent or ubiquitous in the mantle zone of the premam, mam and supramam zones.
TS24: diencephalon ventricular layer Very strong Erbb2-Shh E16.5-sagittal , Erbb2-Shh E16.5-coronal There is very strong staining in the ventricular zone of the premam, mam and supramam zones.
TS24: ganglionic eminence Very strong Non-Uniform Erbb2-Shh E16.5-sagittal , Erbb2-Shh E16.5-coronal There is very strong staining in the ventricular zone of the ganglionic eminences. Staining is either absent or ubiquitous in the mantle zone of the ganglionic eminences.
TS24: hypothalamus mantle layer Ambiguous Erbb2-Shh E16.5-coronal , Erbb2-Shh E16.5-sagittal Staining is either absent or ubiquitous in the mantle zone of the dorsal and ventral POAs, the PVH, SCH, DMH, VMH and ARH nuclei, the AVH, the DAH and the PH.
TS24: hypothalamus ventricular layer Very strong Erbb2-Shh E16.5-sagittal , Erbb2-Shh E16.5-coronal There is very strong staining in the ventricular zone of the dorsal and ventral POAs, the PVH, SCH, DMH, VMH and ARH nuclei, the AVH, the DAH and the PH.
TS24: thalamus mantle layer Weak Scattered Erbb2-Shh E16.5-sagittal , Erbb2-Shh E16.5-coronal There is weak, scattered staining in the mantle zone of the dorsal thalamus and prethalamus.
TS24: thalamus ventricular layer Very strong Erbb2-Shh E16.5-sagittal , Erbb2-Shh E16.5-coronal There is very strong staining in the ventricular zone of the dorsal thalamus and prethalamus.


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory