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Gene Expression Data
Assay Details
Assay
Reference: J:157819 Shimogori T, et al., A genomic atlas of mouse hypothalamic development. Nat Neurosci. 2010;13(6):767-75
Assay type: RNA in situ
MGI Accession ID: MGI:4450817
Gene symbol: Epdr1
Gene name: ependymin related protein 1 (zebrafish)
Probe: UI-M-BG1-aif-f-09-0-UI.s1
Probe preparation: Antisense RNA labelled with digoxigenin
Visualized with: Alkaline phosphatase
Assay notes: These specimens were also hybridized with a fluorescein-labeled Shh probe MGI:2110655; detected with TBT/BCIP. The results are reported in Supp. Table 4, whose legend includes a key to the abbreviations used and more fully details the regions examined.
Results
Specimen Epdr2 - E11.5: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: diencephalon lateral wall mantle layer Ambiguous epdr2-shh e11.5-coronal Staining is either absent or ubiquitous in the mantle zone of the dorsal thalamus, the prethalamus, dorsal and ventral POAs, the PVH, VMH and ARH nuclei, the AVH, the anterior and posterior IDs, the premam, mam and supramam zones and the TT.
TS19: diencephalon lateral wall ventricular layer Moderate Non-Uniform epdr2-shh e11.5-coronal Staining is moderate and scattered in the VZ of dorsal thalamus, prethalamus, dorsal POA, PVH nucleus, anterior & posterior IDs, premam & supramam zones & TT, moderate in mam zone & either absent or ubiquitous in ventral POA, AVH & VMH & ARH nuclei.
TS19: telencephalon mantle layer Ambiguous epdr2-shh e11.5-coronal Staining is either absent or ubiquitous in the postmitotic neurons in the intermediate zone and cortical plate of the cerebral cortex and in the mantle zone of the ganglionic eminences.
TS19: telencephalon ventricular layer Moderate Scattered epdr2-shh e11.5-coronal There is moderate, scattered staining in the ventricular zone of the cerebral cortex and the ganglionic eminences.

Specimen Epdr2 - E12.5: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: cerebral cortex intermediate zone Ambiguous Epdr2-Shh E12.5-coronal Staining is either absent or ubiquitous in the postmitotic neurons in the intermediate zone of the cerebral cortex.
TS20: cerebral cortex ventricular layer Moderate Epdr2-Shh E12.5-coronal There is moderate staining in the ventricular zone of the cerebral cortex.
TS20: cortical plate Ambiguous Epdr2-Shh E12.5-coronal Staining is either absent or ubiquitous in the postmitotic neurons in the cortical plate of the cerebral cortex.
TS20: diencephalon mantle layer Ambiguous Epdr2-Shh E12.5-coronal Staining is either absent or ubiquitous in the mantle zone of the premam, mam and supramam zones and the TT.
TS20: diencephalon ventricular layer Moderate Non-Uniform Epdr2-Shh E12.5-coronal There is moderate staining in the ventricular zone of the mam zone and moderate, scattered staining in the premam and supramam zones and the TT.
TS20: ganglionic eminence Moderate Non-Uniform Epdr2-Shh E12.5-coronal There is moderate, scattered staining in the ventricular zone of the ganglionic eminences. Staining is either absent or ubiquitous in the mantle zone of the ganglionic eminences.
TS20: hypothalamus mantle layer Ambiguous Epdr2-Shh E12.5-coronal Staining is either absent or ubiquitous in the mantle zone of the dorsal and ventral POAs, the PVH, VMH and ARH nuclei, the AVH and anterior and posterior IDs.
TS20: hypothalamus ventricular layer Moderate Non-Uniform Epdr2-Shh E12.5-coronal There is moderate, scattered staining in the VZ of the anterior and posterior IDs and weak, scattered staining in the dorsal POA and the PVH nucleus. Staining is either absent or ubiquitous in the VZ of the ventral POA, AVH and VMH and ARH nuclei.
TS20: thalamus mantle layer Ambiguous Epdr2-Shh E12.5-coronal Staining is either absent or ubiquitous in the mantle zone of the dorsal thalamus and prethalamus.
TS20: thalamus ventricular layer Moderate Epdr2-Shh E12.5-coronal There is moderate staining in the ventricular zone of the dorsal thalamus and prethalamus.

Specimen Epdr2 - E14.5: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: cerebral cortex intermediate zone Ambiguous Epdr2-Shh E14.5-coronal Staining is either absent or ubiquitous in the postmitotic neurons in the intermediate zone of the cerebral cortex.
TS22: cerebral cortex ventricular layer Moderate Epdr2-Shh E14.5-coronal There is moderate, scattered staining in the ventricular zone of the cerebral cortex.
TS22: cortical plate Ambiguous Epdr2-Shh E14.5-coronal Staining is either absent or ubiquitous in the postmitotic neurons in the cortical plate of the cerebral cortex.
TS22: diencephalon mantle layer Ambiguous Epdr2-Shh E14.5-coronal Staining is either absent or ubiquitous in the mantle zone of the premam, mam and supramam zones and the TT.
TS22: diencephalon ventricular layer Moderate Epdr2-Shh E14.5-coronal There is moderate staining in the ventricular zone of the premam, mam and supramam zones and the TT.
TS22: ganglionic eminence Moderate Non-Uniform Epdr2-Shh E14.5-coronal There is moderate, scattered staining in the ventricular zone of the ganglionic eminences. Staining is either absent or ubiquitous in the mantle zone of the ganglionic eminences.
TS22: hypothalamus mantle layer Ambiguous Epdr2-Shh E14.5-coronal Staining is either absent or ubiquitous in the mantle zone of the dorsal and ventral POAs, the PVH, VMH and ARH nuclei, the AVH and anterior and posterior IDs.
TS22: hypothalamus ventricular layer Strong Non-Uniform Epdr2-Shh E14.5-coronal There is strong staining in the VZ of the dorsal POA, moderate staining in the anterior and posterior IDs and the VMH nucleus and weak staining in the PVH and ARH nuclei and the AVH. Staining is either absent or ubiquitous in the VZ of the ventral POA.
TS22: thalamus mantle layer Ambiguous Epdr2-Shh E14.5-coronal Staining is either absent or ubiquitous in the mantle zone of the dorsal thalamus and prethalamus.
TS22: thalamus ventricular layer Strong Non-Uniform Epdr2-Shh E14.5-coronal There is strong staining in the ventricular zone of the prethalamus and moderate staining in the dorsal thalamus.

Specimen Epdr2 - E16.5: embryonic day 16.5 (more )
Structure Level Pattern Image Note
TS24: cerebral cortex intermediate zone Ambiguous Epdr2-Shh E16.5-coronal Staining is either absent or ubiquitous in the postmitotic neurons in the intermediate zone of the cerebral cortex.
TS24: cerebral cortex ventricular layer Weak Scattered Epdr2-Shh E16.5-coronal There is weak, scattered staining in the ventricular zone of the cerebral cortex.
TS24: cortical plate Ambiguous Epdr2-Shh E16.5-coronal Staining is either absent or ubiquitous in the postmitotic neurons in the cortical plate of the cerebral cortex.
TS24: diencephalon mantle layer Ambiguous Epdr2-Shh E16.5-coronal Staining is either absent or ubiquitous in the mantle zone of the premam, mam and supramam zones.
TS24: diencephalon ventricular layer Strong Epdr2-Shh E16.5-coronal There is strong staining in the ventricular zone of the premam, mam and supramam zones.
TS24: ganglionic eminence Ambiguous Epdr2-Shh E16.5-coronal Staining is either absent or ubiquitous in the ventricular and mantle zones of the ganglionic eminences.
TS24: hypothalamus mantle layer Ambiguous Epdr2-Shh E16.5-coronal Staining is either absent or ubiquitous in the mantle zone of the dorsal and ventral POAs, the PVH, SCH, DMH, VMH and ARH nuclei, the AVH, the DAH and the PH.
TS24: hypothalamus ventricular layer Strong Non-Uniform Epdr2-Shh E16.5-coronal There is strong staining in the ventricular zone of the dorsal and ventral POAs, the DMH, VMH and ARH nuclei and the PH and weak staining in the PVH and SCH nuclei, the AVH and the DAH.
TS24: thalamus mantle layer Weak Non-Uniform Epdr2-Shh E16.5-coronal There is weak, scattered staining in the mantle zone of the dorsal thalamus. Staining is either absent or ubiquitous in the mantle zone of the prethalamus.
TS24: thalamus ventricular layer Strong Epdr2-Shh E16.5-coronal There is strong staining in the ventricular zone of the dorsal thalamus and prethalamus.


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last database update
09/22/2020
MGI 6.16
The Jackson Laboratory