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Gene Expression Data
Assay Details
Assay
Reference: J:97231 Koop EA, et al., Receptor protein tyrosine phosphatase mu expression as a marker for endothelial cell heterogeneity; analysis of RPTPmu gene expression using LacZ knock-in mice. Int J Dev Biol. 2003 Jun;47(5):345-54
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:3761810
Gene symbol: Ptprm
Gene name: protein tyrosine phosphatase, receptor type, M
Reporter: lacZ
Direct Detection
Assay notes: Embryos were fixed in 1% paraformaldehyde and 0.2% glutaraldehyde and postfixed in 4% paraformaldehyde.
Results
Specimen Not shown: embryonic day 6.5; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS9: embryo Absent

Specimen 2A: embryonic day 9.5; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS15: Rathke's pouch Present 2A
TS15: diencephalon lamina terminalis Present 2A
TS15: diencephalon roof plate Present 2A
TS15: heart Present 2A
TS15: telencephalon roof plate Present 2A
TS15: blood vessel Present Regionally restricted 2A Expression is in somitic vessels.

Specimen 2B: embryonic day 9.5; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS15: Rathke's pouch Present Spotted 2B

Specimen 2C: embryonic day 9.5; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS15: 1st branchial pouch Present 2C
TS15: 2nd arch artery Present 2C
TS15: 2nd branchial pouch Present 2C

Specimen 2D: embryonic day 9.5; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS15: common atrial chamber endocardial lining Present 2D
TS15: dorsal aorta Present 2D
TS15: primitive ventricle endocardial lining Present 2D
TS15: heart atrium Present Regionally restricted 2D Expression is in the endothelium.

Specimen Not shown: embryonic day 9.5; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS15: olfactory placode Present Regionally restricted Expression is in the olfactory placode, in the dorsal part of the oropharynx.

Specimen 3A: embryonic day 12.5; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS20: choroid invagination Present Regionally restricted 3A Expression is in the choroidal fissure.
TS20: epithalamus Absent 3A
TS20: thalamus Absent 3A

Specimen 3B: embryonic day 12.5; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS20: diencephalon mantle layer Present Regionally restricted 3B Expression is in the mantle layers of the ventricle.
TS20: hindbrain mantle layer Present Regionally restricted 3B Expression is in the mantle layers of the ventricle.
TS20: diencephalon lamina terminalis Present 3B
TS20: diencephalon floor plate Present Regionally restricted 3B
TS20: diencephalon roof plate Present Regionally restricted 3B

Specimen 3C: embryonic day 12.5; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS20: choroid plexus Present Regionally restricted 3C Expression is in the vessels of the choroid plexus.

Specimen 3D: embryonic day 12.5; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS20: olfactory epithelium Present 3D

Specimen 3E: embryonic day 12.5; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS20: atrium endocardial lining Present Regionally restricted 3E Expression is in the endothelium.
TS20: dorsal aorta Present Regionally restricted 3E Expression is in the endothelium.
TS20: ventricle endocardial lining Present Regionally restricted 3E Expression is in the endothelium.

Specimen 3F: embryonic day 12.5; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS20: pulmonary artery Present 3F
TS20: blood vessel Present Regionally restricted 3F Expression is in small vessels in the lung.
TS20: lobar bronchus Absent 3F

Specimen 3G: embryonic day 12.5; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS20: hyaloid cavity Present 3G
TS20: optic stalk Present Regionally restricted 3G Expression is in vessels.

Specimen 3H: embryonic day 12.5; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS20: liver Absent 3H
TS20: venous system Weak Regionally restricted 3H Weak expression in the hepatic vein.

Specimen Not shown: embryonic day 12.5; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS20: cardiovascular system Present Regionally restricted The vasculature showed expression in almost all capillaries and arteries throughout the embryo.

Specimen 4A: postnatal adult; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS28: heart Present 4A

Specimen 4B: postnatal adult; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS28: arterial system Present Regionally restricted 4B Expression is in the endothelium of the coronary arteries.
TS28: heart Present Regionally restricted 4B Expression is in myocytes.

Specimen 4C: postnatal adult; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS28: lung Present 4C

Specimen 4D: postnatal adult; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS28: pulmonary artery Present Regionally restricted 4D Expression is in the endothelium.
TS28: bronchus Absent 4D

Specimen 4E: postnatal adult; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS28: lung alveolus Present Regionally restricted 4E Expression is in type II pneumonocytes of the lung alveoli.

Specimen 4F: postnatal adult; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS28: cerebellum Purkinje cell layer Present 4F

Specimen 4G: postnatal adult; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS28: meninges Present Regionally restricted 4G Expression is in the leptomeninges.

Specimen 4H: postnatal adult; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS28: cerebellum Purkinje cell layer Present 4H

Specimen 4I: postnatal adult; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS28: cerebral cortex Present 4I

Specimen 5A: embryonic day 12.5; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS20: blood vessel Present Regionally restricted 5A Expression is in the capillaries in the brain.

Specimen 5B: embryonic day 12.5; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS20: body wall Present Regionally restricted 5B Expression is in capillaries.
TS20: heart ventricle Present Regionally restricted 5B Expression is in capillaries.

Specimen 5C: embryonic day 12.5; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS20: blood vessel Present Regionally restricted 5C Expression is in capillaries of the stomach.

Specimen 5D: postnatal adult; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS28: capillary Present Regionally restricted 5D Expression is in capillaries of the brain.

Specimen 5E: postnatal adult; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS28: capillary Present Regionally restricted 5E Expression is in capillaries of the heart.

Specimen 5F: postnatal adult; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS28: capillary Present Regionally restricted 5F Expression is in capillaries of skeletal muscle.
TS28: skeletal muscle Absent 5F

Specimen 5G: postnatal adult; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS28: artery Present Regionally restricted 5G Expression is in the small arteries of the liver.

Specimen 5H: postnatal adult; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS28: artery Present Regionally restricted 5H Expression is in the small arteries of the spleen.

Specimen Not shown: postnatal adult; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS28: capillary Present Regionally restricted Expression is in the capillaries of the gut, the gonads, the kidney, and the skeletal muscles.

Specimen 6A: embryonic day 12.5; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS20: dorsal aorta Strong Regionally restricted 6A Expression is in endothelial cells.
TS20: cardinal vein Trace Regionally restricted 6A Expression is in endothelial cells.

Specimen 6B: embryonic day 12.5; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS20: arterial system Strong 6B
TS20: venous system Trace 6B The veins showed low or no expression.

Specimen 6C: embryonic day 12.5; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS20: arterial system Strong Regionally restricted 6C Expression is in the vitelline vessel.
TS20: venous system Trace Regionally restricted 6C Low or absent in the vitelline vessel.

Specimen 6D: embryonic day 12.5; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS20: arterial system Strong 6D Shown is the liver.
TS20: venous system Trace 6D Shown is the liver. Expression in veins is negative or only weakly positive.

Specimen 6E: embryonic day 12.5; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS20: arterial system Strong 6E Shown is the umbilical cord.
TS20: venous system Trace 6E Shown is the umbilical cord. Expression in veins is negative or only weakly positive.

Specimen 6F: embryonic day 12.5; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS20: arterial system Strong 6F Shown is the tail.
TS20: venous system Trace 6F Shown is the tail. Expression in veins is negative or only weakly positive.

Specimen 7A,B: postnatal adult; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS28: artery Present 7A , 7B Shown is the bladder.
TS28: vein Absent 7A , 7B Shown is the bladder.

Specimen 7C,D: postnatal adult; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS28: artery Present 7D , 7C Shown are the seminal vesicles.
TS28: vein Absent 7D , 7C Shown are the seminal vesicles.

Specimen 7E,F: postnatal adult; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS28: artery Present 7F , 7E Shown is the uterus.
TS28: vein Absent 7E , 7F Shown is the uterus.

Specimen 8A,D: embryonic day 9.5; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS15: dorsal aorta Present Regionally restricted 8A , 8D Expression is in the endothelium.
TS15: arterial system Present Regionally restricted 8A , 8D Expression is in the endothelium of the ductus arteriosus.
TS15: endocardial lining Present 8D , 8A

Specimen 8B,E: embryonic day 12.5; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS20: dorsal aorta Present Regionally restricted 8B , 8E Expression is in the endothelium.
TS20: arterial system Present Regionally restricted 8E , 8B Expression is in the endothelium of the ductus arteriosus.
TS20: endocardial lining Present 8B , 8E

Specimen 8C: postnatal adult; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS28: aorta Absent 8C Absent in the aorta itself, but is present in the side branches.

Specimen 8F: postnatal adult; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS28: heart ventricle Absent 8F


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/19/2021
MGI 6.17
The Jackson Laboratory