Gata1tm5(GATA3)Sho
Targeted Allele Detail
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| Symbol: |
Gata1tm5(GATA3)Sho |
| Name: |
GATA binding protein 1; targeted mutation 5, Stuart Orkin |
| MGI ID: |
MGI:2429992 |
| Synonyms: |
G1G3ki |
| Gene: |
Gata1 Location: ChrX:7825504-7842844 bp, - strand Genetic Position: ChrX, 3.59 cM, cytoband A2
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| Alliance: |
Gata1tm5(GATA3)Sho page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:47295
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| Parent Cell Line: |
J1 (ES Cell)
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| Strain of Origin: |
129S4/SvJae
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| Allele Type: |
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Targeted |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Sequence extending from the start codon in exon 2 to the EcoRI site in exon 3 was replaced with a construct containing human GATA3 cDNA sequence followed by a floxed PGK-neo cassette. Northern blot analyses of cell lines derived from mutant embryos indicated that a transcript comprised of both GATA3 and Gata1 sequence was expressed in erythroid cells (but not in myeloid cells). The presence of a protein translated from GATA3 sequence was verified by immunostaining. No Gata1 protein was detected.
(J:47295)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Gata1 Mutation: |
44 strains or lines available
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| Original: |
J:47295 Tsai FY, et al., Knock-in mutation of transcription factor GATA-3 into the GATA-1 locus: partial rescue of GATA-1 loss of function in erythroid cells. Dev Biol. 1998 Apr 15;196(2):218-27 |
| All: |
1 reference(s) |
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Analysis Tools
