Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Fzd3tm1Nat
Name:	frizzled class receptor 3; targeted mutation 1, Jeremy Nathans
MGI ID:	MGI:2388632
Synonyms:	fz3(-)
Gene:	Fzd3  Location: Chr14:65429898-65499912 bp, - strand  Genetic Position: Chr14, 34.09 cM
Alliance:	Fzd3tm1Nat page

Germline Transmission:	Earliest citation of germline transmission: J:79213
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: The coding regions of the exons 1 and 2 were replaced with a cassette containing lacZ and neo genes. The deleted region encoded the amino terminal signal sequence and a conserved extracellular domain that has been previously been shown to be involved wiht Wnt binding. The expression pattern of beta-galactosidase replicated that of the endogenous gene. (J:79213)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	9 assay results
In Structures Affected by this Mutation:	11 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fzd3 Mutation:	32 strains or lines available

Original:	J:79213 Wang Y, et al., Frizzled-3 is required for the development of major fiber tracts in the rostral CNS. J Neurosci. 2002 Oct 1;22(19):8563-73
All:	21 reference(s)