Summary | Mutation origin | Mutation description | Expression | Find Mice (IMSR) | References

Symbol:	RestGt(D047E11)Wrst
Name:	RE1-silencing transcription factor; gene trap D047E11, German Gene Trap Consortium
MGI ID:	MGI:3873420
Gene:	Rest  Location: Chr5:77413338-77434279 bp, + strand  Genetic Position: Chr5, 41.61 cM
Alliance:	RestGt(D047E11)Wrst page

Mutant Cell Line:	D047E11
Germline Transmission:	Earliest citation of germline transmission: J:229930
Parent Cell Line:	TBV2 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Gene trapped (Null/knockout, Reporter) Mutation:    Insertion of gene trap vector     Vector: rFlpROSAbetageo   Mutation details: A gene trap vector inserted in the intron between non-coding exon 1ac and the first coding exon, exon 2. The construct contains a splice acceptor site upstream of a promoter-less beta-galactosidase and neomycin gene fusion (beta-geo) and a polyadenylation sequence. Beta-geo expression in this line is under the control of endogenous regulatory elements for this gene. Loss of both enndogenous protein and messenger RNA was observed. (J:229930) Sequence Tags:  Sequence tag details (1 tag) Tag ID GenBank ID Method Tag Location (trapped strand)* Select D047E11 DU821609 (MGI Seq Detail) 5' RACE Chr5:77408184-77408320 bp (+) * GRCm39 (strand of gene trap mutagenesis) Selected Tags: download BLAST at NCBI Genome Context:  Genome Browser view of this mutation 129 gene trap insertions have trapped this gene View all gene trap sequence tags in this region

In Mice Carrying this Mutation:

3 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rest Mutation:	95 strains or lines available

Original:	J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008;
All:	7 reference(s)