Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Cd44tm1.2Mka
Name:	CD44 antigen; targeted mutation 1.2, Michael Karin
MGI ID:	MGI:6468311
Synonyms:	cd44-
Gene:	Cd44  Location: Chr2:102641486-102732010 bp, - strand  Genetic Position: Chr2, 54.13 cM
Alliance:	Cd44tm1.2Mka page

Germline Transmission:	Earliest citation of germline transmission: J:296234
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S/SvEv

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Exon 3 was flanked with loxP sites. An frt-flanked neomycin selection cassette was removed in ES cells prior to the creation of chimeric mice. Cre-mediated recombination in the germline resulted in the deletion of exon 3. (J:296234)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd44 Mutation:	67 strains or lines available

Original:	J:296234 Ma J, et al., Cluster of differentiation 44 promotes osteosarcoma progression in mice lacking the tumor suppressor Merlin. Int J Cancer. 2020 Jun 11;
All:	3 reference(s)