Slc25a1tm1c(EUCOMM)Wtsi
Targeted Allele Detail
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| Symbol: |
Slc25a1tm1c(EUCOMM)Wtsi |
| Name: |
solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1; targeted mutation 1c, Wellcome Trust Sanger Institute |
| MGI ID: |
MGI:6449056 |
| Synonyms: |
Slc25a1fl |
| Gene: |
Slc25a1 Location: Chr16:17743087-17746083 bp, - strand Genetic Position: Chr16, 11.11 cM, cytoband B1
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| Alliance: |
Slc25a1tm1c(EUCOMM)Wtsi page
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| IMPC: |
Slc25a1 gene page |
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| Germline Transmission: |
Earliest citation of germline transmission:
J:291363
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| Parent Cell Line: |
JM8A1.N3 (ES Cell)
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| Strain of Origin: |
C57BL/6N-Atm1Brd
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| Project Collection: |
EUCOMM
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| Allele Type: |
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Targeted (Conditional ready) |
| Mutation: |
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Insertion
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Mutation details: The L1L2_Bact_P cassette was inserted at position 17744985 of Chromosome 16 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 17745817. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking the critical exon(s). Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml
(J:291363)
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| Original: |
J:291363 Tan M, et al., Inhibition of the mitochondrial citrate carrier, Slc25a1, reverts steatosis, glucose intolerance, and inflammation in preclinical models of NAFLD/NASH. Cell Death Differ. 2020 Jul;27(7):2143-2157 |
| All: |
2 reference(s) |
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Analysis Tools
