Summary | Mutation origin | Mutation description | Find Mice (IMSR) | Notes | References

Symbol:	Hnf1atm1.1Smoc
Name:	HNF1 homeobox A; targeted mutation 1.1, Shanghai Model Organisms Center
MGI ID:	MGI:6430634
Synonyms:	Hnf1alphaf
Gene:	Hnf1a  Location: Chr5:115087039-115109121 bp, - strand  Genetic Position: Chr5, 55.99 cM, cytoband F
Alliance:	Hnf1atm1.1Smoc page

Germline Transmission:	Earliest citation of germline transmission: J:244892
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Conditional ready) Mutation:    Insertion   Mutation details: A loxP site and a Frt-flanked PgkNeopolyA cassette were inserted into the second intron of the gene, and a second loxP site was inserted into the third intron. The neomycin selection cassette was removed via FLP-mediated recombination in the germline. (J:244892)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hnf1a Mutation:	29 strains or lines available

Original:	J:244892 Ni Q, et al., Deletion of HNF1alpha in hepatocytes results in fatty liver-related hepatocellular carcinoma in mice. FEBS Lett. 2017 Jul;591(13):1947-1957
All:	1 reference(s)