Ggt1tm1c(EUCOMM)Wtsi
Targeted Allele Detail
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Symbol: |
Ggt1tm1c(EUCOMM)Wtsi |
Name: |
gamma-glutamyltransferase 1; targeted mutation 1c, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:6416330 |
Gene: |
Ggt1 Location: Chr10:75397438-75422034 bp, + strand Genetic Position: Chr10, 38.55 cM
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Alliance: |
Ggt1tm1c(EUCOMM)Wtsi page
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IMPC: |
Ggt1 gene page |
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Mutant Cell Line: |
EPD0183_3_C02 |
Germline Transmission: |
Earliest citation of germline transmission:
J:169366
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Parent Cell Line: |
JM8.N4 (ES Cell)
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Strain of Origin: |
C57BL/6N
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Project Collection: |
EUCOMM
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutation: |
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Insertion
Vector: L1L2_Bact_P
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Mutation details: The L1L2_Bact_P cassette was inserted at position 75411301 of Chromosome 10 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 75412486. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml
(J:169366)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Ggt1 Mutation: |
50 strains or lines available
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Original: |
J:169366 MouseBookTM, Information obtained from MouseBookTM, Medical Research Council Mammalian Genetics Unit, Harwell, UK. Unpublished. 2005-2013; |
All: |
1 reference(s) |
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