Foxa2tm1.1Khk
Targeted Allele Detail
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Symbol: |
Foxa2tm1.1Khk |
Name: |
forkhead box A2; targeted mutation 1.1, Kalus H Kaestner |
MGI ID: |
MGI:6393315 |
Gene: |
Foxa2 Location: Chr2:147884797-147888889 bp, - strand Genetic Position: Chr2, 73.38 cM
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Alliance: |
Foxa2tm1.1Khk page
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Germline Transmission: |
Earliest citation of germline transmission:
J:284174
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Parent Cell Line: |
E14.1 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A single loxP site was inserted into intron 2 and a loxP flanked neomycin and thymidine kinase selection cassette was inserted into intron 3. The selection cassette was removed in ES cells by transient Cre expression prior to the production of chimeric mice, leaving exon 2 flanked by loxP sites in the final allele. Cre-mediated recombination deleted exon 2 in the germline.
(J:63039, J:284174)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Foxa2 Mutation: |
26 strains or lines available
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Original: |
J:63039 Sund NJ, et al., Hepatocyte nuclear factor 3beta (Foxa2) is dispensable for maintaining the differentiated state of the adult hepatocyte. Mol Cell Biol. 2000 Jul;20(14):5175-83 |
All: |
2 reference(s) |
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