Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Esrratm1.1Dpm
Name:	estrogen related receptor, alpha; targeted mutation 1.1, Donald McDonnell
MGI ID:	MGI:6393265
Gene:	Esrra  Location: Chr19:6888345-6899182 bp, - strand  Genetic Position: Chr19, 5.08 cM
Alliance:	Esrratm1.1Dpm page

Germline Transmission:	Earliest citation of germline transmission: J:278512
Parent Cell Line:	G4 (ES Cell)
Strain of Origin:	(129S6/SvEvTac x C57BL/6NCrl)F1

Allele Type:    Targeted (Conditional ready) Mutation:    Insertion   Mutation details: The targeting vector was constructed to insert a loxP site and a FRT-flanked neomycin selection cassette upstream of exon 2 and another loxP site downstream of exon 2. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exon 2 floxed. (J:278512)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Esrra Mutation:	25 strains or lines available

Original:	J:278512 Racioppi L, et al., CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer. Nat Commun. 2019 Jun 4;10(1):2450
All:	1 reference(s)