Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Pigutm1c(EUCOMM)Hmgu
Name:	phosphatidylinositol glycan anchor biosynthesis, class U; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
MGI ID:	MGI:6368162
Gene:	Pigu  Location: Chr2:155120163-155199344 bp, - strand  Genetic Position: Chr2, 77.18 cM
Alliance:	Pigutm1c(EUCOMM)Hmgu page

Mutant Cell Line:	HEPD0536_5_F10
Germline Transmission:	Earliest citation of germline transmission: J:303166
Parent Cell Line:	JM8.N4 (ES Cell)
Strain of Origin:	C57BL/6N

Allele Type:    Targeted (Conditional ready) Mutation:    Insertion     Vector: L1L2_st1   Mutation details: The L1L2_st1 cassette was inserted at a position on Chromosome 2 upstream of exon 2 of the gene. The cassette is composed of an FRT-flanked lacZ sequence fused to a neomycin sequence followed by a loxP site. A second loxP site was inserted downstream of exon 3. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking exon 3. (J:303166)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pigu Mutation:	24 strains or lines available

Original:	J:303166 Vacaresse N, et al., The Glycosylphosphatidylinositol Anchor Regulates T Cell Antigen Receptor Induced IL-2 Production. Open Journal of Immunology. 2021;11:1-24
All:	1 reference(s)