Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Gpr132tm1Witt
Name:	G protein-coupled receptor 132; targeted mutation 1, Owen N Witte
MGI ID:	MGI:2388138
Synonyms:	G2A-
Gene:	Gpr132  Location: Chr12:112814493-112831848 bp, - strand  Genetic Position: Chr12, 61.25 cM, cytoband F2
Alliance:	Gpr132tm1Witt page

Germline Transmission:	Earliest citation of germline transmission: J:69473
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: The gene was disrupted by replacement of exon 2 (98% of the total coding sequence) with an IRES-lacZ-PGK-neo cassette. Absence of gene expression was confirmed by RT-PCR analysis of pre-B and -T cells from homozygous mutant animals. (J:69473)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

8 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gpr132 Mutation:	23 strains or lines available

Original:	J:69473 Le LQ, et al., Mice lacking the orphan G protein-coupled receptor G2A develop a late-onset autoimmune syndrome. Immunity. 2001 May;14(5):561-71
All:	17 reference(s)