Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Mecp2em1Smoc
Name:	methyl CpG binding protein 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
MGI ID:	MGI:6361658
Synonyms:	Mecp2deltaAT-hook1
Gene:	Mecp2  Location: ChrX:73070198-73129296 bp, - strand  Genetic Position: ChrX, 37.63 cM
Alliance:	Mecp2em1Smoc page

Strain of Origin:

C57BL/6

Allele Type:    Endonuclease-mediated (Not Specified) Mutation:    Intragenic deletion     CRISPR-targeting deleted eight conserved amino acids, RGRGRPKG, aa 186-193 in the AT-hook 1 domain. (J:256748)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mecp2 Mutation:	38 strains or lines available

Original:	J:256748 Xu M, et al., Disruption of AT-hook 1 domain in MeCP2 protein caused behavioral abnormality in mice. Biochim Biophys Acta. 2017 Oct 24;1864(2):347-358
All:	1 reference(s)