Il1btm1c(EUCOMM)Hmgu
Targeted Allele Detail
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Symbol: |
Il1btm1c(EUCOMM)Hmgu |
Name: |
interleukin 1 beta; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH |
MGI ID: |
MGI:6358097 |
Synonyms: |
Il1bfl |
Gene: |
Il1b Location: Chr2:129206490-129213059 bp, - strand Genetic Position: Chr2, 62.97 cM, cytoband F
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Alliance: |
Il1btm1c(EUCOMM)Hmgu page
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IMPC: |
Il1b gene page |
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Mutant Cell Line: |
HEPD0840_8_E03 |
Germline Transmission: |
Earliest citation of germline transmission:
J:278482
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Parent Cell Line: |
JM8.N4 (ES Cell)
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Strain of Origin: |
C57BL/6N
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Project Collection: |
EUCOMM
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Allele Type: |
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Targeted (Conditional ready) |
Mutation: |
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Insertion
Vector: L1L2_Bact_P
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Mutation details: The L1L2_Bact_P cassette was inserted at position 129208682 of Chromosome 2 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 129210342. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking the critical exon(s). Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml
(J:278482)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Il1b Mutation: |
24 strains or lines available
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Original: |
J:278482 Helyes Z, et al., Transfer of complex regional pain syndrome to mice via human autoantibodies is mediated by interleukin-1-induced mechanisms. Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):13067-13076 |
All: |
5 reference(s) |
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