Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Klhl2em1Esoh
Name:	kelch-like 2, Mayven; endonuclease-mediated mutation 1, Eisei Sohara
MGI ID:	MGI:6355952
Synonyms:	7 bp deletion, KLHL2-
Gene:	Klhl2  Location: Chr8:65192709-65302669 bp, - strand  Genetic Position: Chr8, 32.3 cM
Alliance:	Klhl2em1Esoh page

Strain of Origin:

C57BL/6

Allele Type:    Endonuclease-mediated (Null/knockout) Mutation:    Intragenic deletion   Mutation details: CRISPR/Cas9 mutagenesis induced a 7 bp deletion in exon 3, resulting in a stop codon after the 86th amino acid in the encoded protein. Immunoblot analysis confirmed the absence of protein expression in the kidneys of homozygous mutant mice. (J:250869)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Klhl2 Mutation:	31 strains or lines available

Original:	J:250869 Kasagi Y, et al., Impaired degradation of medullary WNK4 in the kidneys of KLHL2 knockout mice. Biochem Biophys Res Commun. 2017 May 27;487(2):368-374
All:	1 reference(s)