Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Rr102tm1.1Ics
Name:	regulatory region 102; targeted mutation 1.1, Mouse Clinical Institute
MGI ID:	MGI:6336128
Synonyms:	Egr2tm1.1Ics, Krox20A*
Gene:	Rr102  Location: unknown  Genetic Position: Chr10, Syntenic
Alliance:	Rr102tm1.1Ics page

Germline Transmission:	Earliest citation of germline transmission: J:277269
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Conditional ready, Modified regulatory region) Mutations:    Insertion, Intragenic deletion   Mutation details: An FRT site flanked neomycin resistance gene cassette and a loxP site flanked chicken transcriptional enhancer element A that contains specific mutations in the Egr2 binding sites that prevent binding of wild-type Egr2 and instead allow binding of a mutant Egr2 (Krox20) protein, and an F3 site flanked mouse element A replaced the wild-type autoregulatory element A. Flp-mediated recombination removed the F3 flanked mouse element A and the neo cassette such that the chicken element A is expressed. (J:277269)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rr102 Mutation:	0 strains or lines available

Original:	J:277269 Bouchoucha YX, et al., Dissection of a Krox20 positive feedback loop driving cell fate choices in hindbrain patterning. Mol Syst Biol. 2013;9:690
All:	1 reference(s)